This old version of Proteopedia is provided for student assignments while the new version is undergoing repairs. Content and edits done in this old version of Proteopedia after March 1, 2026 will eventually be lost when it is retired in about June of 2026.

Apply for new accounts at the new Proteopedia. Your logins will work in both the old and new versions.


2j51

From Proteopedia

(Difference between revisions)
Jump to: navigation, search
Current revision (14:34, 13 December 2023) (edit) (undo)
 
(2 intermediate revisions not shown.)
Line 1: Line 1:
==Crystal structure of Human STE20-like kinase bound to 5-Amino-3-((4-(aminosulfonyl)phenyl)amino) -N-(2,6-difluorophenyl)-1H-1,2,4-triazole- 1-carbothioamide==
==Crystal structure of Human STE20-like kinase bound to 5-Amino-3-((4-(aminosulfonyl)phenyl)amino) -N-(2,6-difluorophenyl)-1H-1,2,4-triazole- 1-carbothioamide==
-
<StructureSection load='2j51' size='340' side='right' caption='[[2j51]], [[Resolution|resolution]] 2.10&Aring;' scene=''>
+
<StructureSection load='2j51' size='340' side='right'caption='[[2j51]], [[Resolution|resolution]] 2.10&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
-
<table><tr><td colspan='2'>[[2j51]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2J51 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2J51 FirstGlance]. <br>
+
<table><tr><td colspan='2'>[[2j51]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2J51 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2J51 FirstGlance]. <br>
-
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=DKI:5-AMINO-3-{[4-(AMINOSULFONYL)PHENYL]AMINO}-N-(2,6-DIFLUOROPHENYL)-1H-1,2,4-TRIAZOLE-1-CARBOTHIOAMIDE'>DKI</scene>, <scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=SCN:THIOCYANATE+ION'>SCN</scene></td></tr>
+
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.1&#8491;</td></tr>
-
<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Non-specific_serine/threonine_protein_kinase Non-specific serine/threonine protein kinase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.11.1 2.7.11.1] </span></td></tr>
+
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=DKI:5-AMINO-3-{[4-(AMINOSULFONYL)PHENYL]AMINO}-N-(2,6-DIFLUOROPHENYL)-1H-1,2,4-TRIAZOLE-1-CARBOTHIOAMIDE'>DKI</scene>, <scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=SCN:THIOCYANATE+ION'>SCN</scene></td></tr>
-
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2j51 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2j51 OCA], [http://pdbe.org/2j51 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2j51 RCSB], [http://www.ebi.ac.uk/pdbsum/2j51 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=2j51 ProSAT]</span></td></tr>
+
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2j51 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2j51 OCA], [https://pdbe.org/2j51 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2j51 RCSB], [https://www.ebi.ac.uk/pdbsum/2j51 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2j51 ProSAT]</span></td></tr>
</table>
</table>
 +
== Function ==
 +
[https://www.uniprot.org/uniprot/SLK_HUMAN SLK_HUMAN] Mediates apoptosis and actin stress fiber dissolution.
== Evolutionary Conservation ==
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
[[Image:Consurf_key_small.gif|200px|right]]
Line 31: Line 33:
__TOC__
__TOC__
</StructureSection>
</StructureSection>
-
[[Category: Human]]
+
[[Category: Homo sapiens]]
-
[[Category: Non-specific serine/threonine protein kinase]]
+
[[Category: Large Structures]]
-
[[Category: Arrowsmith, C]]
+
[[Category: Arrowsmith C]]
-
[[Category: Debreczeni, J E]]
+
[[Category: Debreczeni JE]]
-
[[Category: Delft, F von]]
+
[[Category: Edwards A]]
-
[[Category: Edwards, A]]
+
[[Category: Fedorov O]]
-
[[Category: Fedorov, O]]
+
[[Category: Keates T]]
-
[[Category: Keates, T]]
+
[[Category: Knapp S]]
-
[[Category: Knapp, S]]
+
[[Category: Papagrigoriou E]]
-
[[Category: Papagrigoriou, E]]
+
[[Category: Pike ACW]]
-
[[Category: Pike, A C.W]]
+
[[Category: Rellos P]]
-
[[Category: Rellos, P]]
+
[[Category: Salah E]]
-
[[Category: Salah, E]]
+
[[Category: Savitsky P]]
-
[[Category: Savitsky, P]]
+
[[Category: Sundstrom M]]
-
[[Category: Sundstrom, M]]
+
[[Category: Turnbull AP]]
-
[[Category: Turnbull, A P]]
+
[[Category: Weigelt J]]
-
[[Category: Weigelt, J]]
+
[[Category: Von Delft F]]
-
[[Category: Apoptosis]]
+
-
[[Category: Atp-binding]]
+
-
[[Category: Germinal centre kinase]]
+
-
[[Category: Kinase]]
+
-
[[Category: Muscle development]]
+
-
[[Category: Nucleotide-binding]]
+
-
[[Category: Phosphorylation]]
+
-
[[Category: Serine/threonine kinase 2]]
+
-
[[Category: Serine/threonine-protein kinase]]
+
-
[[Category: Transferase]]
+

Current revision

Crystal structure of Human STE20-like kinase bound to 5-Amino-3-((4-(aminosulfonyl)phenyl)amino) -N-(2,6-difluorophenyl)-1H-1,2,4-triazole- 1-carbothioamide

PDB ID 2j51

Drag the structure with the mouse to rotate

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/2j51"
Personal tools