2jpz

<StructureSection load='2jpz' size='340' side='right' caption='[[2jpz]], [[NMR_Ensembles_of_Models | 10 NMR models]]' scene=''>

<table><tr><td colspan='2'>[[2jpz]] is a 1 chain structure. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2JPZ OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2JPZ FirstGlance]. <br>

</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[2hy9|2hy9]], [[2kka|2kka]]</td></tr>

<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2jpz FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2jpz OCA], [http://pdbe.org/2jpz PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2jpz RCSB], [http://www.ebi.ac.uk/pdbsum/2jpz PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=2jpz ProSAT]</span></td></tr>

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== Publication Abstract from PubMed ==

Formation of the G-quadruplex in the human telomeric sequence can inhibit the activity of telomerase, thus the intramolecular telomeric G-quadruplexes have been considered as an attractive anticancer target. Information of intramolecular telomeric G-quadruplex structures formed under physiological conditions is important for structure-based drug design. Here, we report the first structure of the major intramolecular G-quadruplex formed in a native, non-modified human telomeric sequence in K(+) solution. This is a hybrid-type mixed parallel/antiparallel-G-stranded G-quadruplex, one end of which is covered by a novel T:A:T triple capping structure. This structure (Hybrid-2) and the previously reported Hybrid-1 structure differ in their loop arrangements, strand orientations and capping structures. The distinct capping structures appear to be crucial for the favored formation of the specific hybrid-type intramolecular telomeric G-quadruplexes, and may provide specific binding sites for drug targeting. Our study also shows that while the hybrid-type G-quadruplexes appear to be the major conformations in K(+) solution, human telomeric sequences are always in equilibrium between Hybrid-1 and Hybrid-2 structures, which is largely determined by the 3'-flanking sequence. Furthermore, both hybrid-type G-quadruplexes suggest a straightforward means for multimer formation with effective packing in the human telomeric sequence and provide important implications for drug targeting of G-quadruplexes in human telomeres.

Structure of the Hybrid-2 type intramolecular human telomeric G-quadruplex in K+ solution: insights into structure polymorphism of the human telomeric sequence.,Dai J, Carver M, Punchihewa C, Jones RA, Yang D Nucleic Acids Res. 2007;35(15):4927-40. Epub 2007 Jul 10. PMID:17626043<ref>PMID:17626043</ref>

From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>

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<div class="pdbe-citations 2jpz" style="background-color:#fffaf0;"></div>

== References ==

<references/>

[[Category: Carver, M]]

[[Category: Dai, J]]

[[Category: Jones, R]]

[[Category: Punchihewa, C]]

[[Category: Yang, D]]

[[Category: Quadruplex]]