2jdq

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==C-terminal domain of influenza A virus polymerase PB2 subunit in complex with human importin alpha5==
==C-terminal domain of influenza A virus polymerase PB2 subunit in complex with human importin alpha5==
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<StructureSection load='2jdq' size='340' side='right' caption='[[2jdq]], [[Resolution|resolution]] 2.20&Aring;' scene=''>
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<StructureSection load='2jdq' size='340' side='right'caption='[[2jdq]], [[Resolution|resolution]] 2.20&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[2jdq]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/9infa 9infa] and [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2JDQ OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2JDQ FirstGlance]. <br>
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<table><tr><td colspan='2'>[[2jdq]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] and [https://en.wikipedia.org/wiki/Influenza_A_virus Influenza A virus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2JDQ OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2JDQ FirstGlance]. <br>
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</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[2gmo|2gmo]]</td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.2&#8491;</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2jdq FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2jdq OCA], [http://pdbe.org/2jdq PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2jdq RCSB], [http://www.ebi.ac.uk/pdbsum/2jdq PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=2jdq ProSAT]</span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2jdq FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2jdq OCA], [https://pdbe.org/2jdq PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2jdq RCSB], [https://www.ebi.ac.uk/pdbsum/2jdq PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2jdq ProSAT]</span></td></tr>
</table>
</table>
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== Function ==
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[https://www.uniprot.org/uniprot/IMA5_HUMAN IMA5_HUMAN] Functions in nuclear protein import as an adapter protein for nuclear receptor KPNB1. Binds specifically and directly to substrates containing either a simple or bipartite NLS motif. Docking of the importin/substrate complex to the nuclear pore complex (NPC) is mediated by KPNB1 through binding to nucleoporin FxFG repeats and the complex is subsequently translocated through the pore by an energy requiring, Ran-dependent mechanism. At the nucleoplasmic side of the NPC, Ran binds to importin-beta and the three components separate and importin-alpha and -beta are re-exported from the nucleus to the cytoplasm where GTP hydrolysis releases Ran from importin. The directionality of nuclear import is thought to be conferred by an asymmetric distribution of the GTP- and GDP-bound forms of Ran between the cytoplasm and nucleus. In vitro, mediates the nuclear import of human cytomegalovirus UL84 by recognizing a non-classical NLS.
== Evolutionary Conservation ==
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
[[Image:Consurf_key_small.gif|200px|right]]
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==See Also==
==See Also==
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*[[Importin|Importin]]
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*[[Importin 3D structures|Importin 3D structures]]
== References ==
== References ==
<references/>
<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Human]]
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[[Category: Homo sapiens]]
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[[Category: Baudin, F]]
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[[Category: Influenza A virus]]
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[[Category: Boulo, S]]
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[[Category: Large Structures]]
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[[Category: Cusack, S]]
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[[Category: Baudin F]]
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[[Category: Guilligay, D]]
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[[Category: Boulo S]]
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[[Category: Hart, D J]]
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[[Category: Cusack S]]
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[[Category: Mas, P]]
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[[Category: Guilligay D]]
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[[Category: Ruigrok, R W.H]]
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[[Category: Hart DJ]]
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[[Category: Tarendeau, F]]
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[[Category: Mas P]]
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[[Category: Armadillo repeat]]
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[[Category: Ruigrok RWH]]
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[[Category: Bipartite nuclear localisation signal]]
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[[Category: Tarendeau F]]
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[[Category: Host-virus interaction]]
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[[Category: Human importin alpha5]]
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[[Category: Influenza a virus rna-dependent rna polymerase]]
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[[Category: Nuclear import adapter]]
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[[Category: Nuclear protein]]
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[[Category: Pb2 subunit]]
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[[Category: Protein transport]]
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[[Category: Transport]]
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Current revision

C-terminal domain of influenza A virus polymerase PB2 subunit in complex with human importin alpha5

PDB ID 2jdq

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