2jp6
From Proteopedia
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==Structural and functional characterization of the recombinant form of the Kv1.3 channel blocker Tc32== | ==Structural and functional characterization of the recombinant form of the Kv1.3 channel blocker Tc32== | ||
| - | <StructureSection load='2jp6' size='340' side='right' caption='[[2jp6 | + | <StructureSection load='2jp6' size='340' side='right'caption='[[2jp6]]' scene=''> |
== Structural highlights == | == Structural highlights == | ||
| - | <table><tr><td colspan='2'>[[2jp6]] is a 1 chain structure. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2JP6 OCA]. For a <b>guided tour on the structure components</b> use [ | + | <table><tr><td colspan='2'>[[2jp6]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Tityus_obscurus Tityus obscurus]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2JP6 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2JP6 FirstGlance]. <br> |
| - | </td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[ | + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR, 25 models</td></tr> |
| + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2jp6 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2jp6 OCA], [https://pdbe.org/2jp6 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2jp6 RCSB], [https://www.ebi.ac.uk/pdbsum/2jp6 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2jp6 ProSAT]</span></td></tr> | ||
</table> | </table> | ||
== Function == | == Function == | ||
| - | [ | + | [https://www.uniprot.org/uniprot/KA181_TITOB KA181_TITOB] Reversible blocker of both Kv1.3/KCNA3 potassium channels (high affinity) and Shaker B (mammalian Kv1.1 analog) potassium channels (very low affinity).<ref>PMID:12445473</ref> |
==See Also== | ==See Also== | ||
| - | *[[Potassium channel toxin|Potassium channel toxin]] | + | *[[Potassium channel toxin 3D structures|Potassium channel toxin 3D structures]] |
== References == | == References == | ||
<references/> | <references/> | ||
__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
| - | [[Category: Belluzzi | + | [[Category: Large Structures]] |
| - | [[Category: Pertinhez | + | [[Category: Tityus obscurus]] |
| - | [[Category: Pignatelli | + | [[Category: Belluzzi O]] |
| - | [[Category: Sforca | + | [[Category: Pertinhez TA]] |
| - | [[Category: Spisni | + | [[Category: Pignatelli A]] |
| - | [[Category: Stehling | + | [[Category: Sforca ML]] |
| - | [[Category: Zanchin | + | [[Category: Spisni A]] |
| - | + | [[Category: Stehling EG]] | |
| + | [[Category: Zanchin NI]] | ||
Current revision
Structural and functional characterization of the recombinant form of the Kv1.3 channel blocker Tc32
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