6e0m
From Proteopedia
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| - | '''Unreleased structure''' | ||
| - | + | ==Structure of Elizabethkingia meningoseptica CdnE cyclic dinucleotide synthase== | |
| - | + | <StructureSection load='6e0m' size='340' side='right'caption='[[6e0m]], [[Resolution|resolution]] 1.52Å' scene=''> | |
| - | + | == Structural highlights == | |
| - | + | <table><tr><td colspan='2'>[[6e0m]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Elizabethkingia_meningoseptica_ATCC_13253_=_NBRC_12535 Elizabethkingia meningoseptica ATCC 13253 = NBRC 12535]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6E0M OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6E0M FirstGlance]. <br> | |
| - | + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.52Å</td></tr> | |
| - | [[Category: | + | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=DPO:DIPHOSPHATE'>DPO</scene></td></tr> |
| + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6e0m FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6e0m OCA], [https://pdbe.org/6e0m PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6e0m RCSB], [https://www.ebi.ac.uk/pdbsum/6e0m PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6e0m ProSAT]</span></td></tr> | ||
| + | </table> | ||
| + | == Function == | ||
| + | [https://www.uniprot.org/uniprot/CDNE_ELIME CDNE_ELIME] CBASS (cyclic oligonucleotide-based antiphage signaling system) provides immunity against bacteriophage. The CD-NTase protein synthesizes cyclic nucleotides in response to infection; these serve as specific second messenger signals. The signals activate a diverse range of effectors, leading to bacterial cell death and thus abortive phage infection. A type I-A(GA) CBASS system (PubMed:32839535).<ref>PMID:32839535</ref> Cyclic dinucleotide synthase that catalyzes the synthesis of 3'3'-cyclic GMP-AMP (cGAMP) from GTP and ATP, and of c-di-AMP and c-di-GMP, that are second messengers for cell signal transduction.<ref>PMID:30787435</ref> | ||
| + | == References == | ||
| + | <references/> | ||
| + | __TOC__ | ||
| + | </StructureSection> | ||
| + | [[Category: Elizabethkingia meningoseptica ATCC 13253 = NBRC 12535]] | ||
| + | [[Category: Large Structures]] | ||
| + | [[Category: Eaglesham JB]] | ||
| + | [[Category: King DS]] | ||
| + | [[Category: Kranzusch PJ]] | ||
| + | [[Category: Lee ASY]] | ||
| + | [[Category: Mekalanos JJ]] | ||
| + | [[Category: Morehouse BR]] | ||
| + | [[Category: Nieminen EA]] | ||
| + | [[Category: Whiteley AT]] | ||
| + | [[Category: De Oliveira Mann CC]] | ||
Current revision
Structure of Elizabethkingia meningoseptica CdnE cyclic dinucleotide synthase
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