6e0t

Structural highlights

Function

OFD1_SCHPO Prolyl 3,4-dihydroxylase that catalyzes 3,4-dihydroxylation of 'Pro-62' of small ribosomal subunit uS12 (rps23 and rps2302), thereby regulating protein translation termination efficiency. Negative regulator of the stability of the N-terminal transcription factor domain (Sre1N) of sre1 which is released from the membrane and enters the nucleus to activate hypoxic gene expression.^{[1] [2]}

References

1. ↑ Lee CY, Stewart EV, Hughes BT, Espenshade PJ. Oxygen-dependent binding of Nro1 to the prolyl hydroxylase Ofd1 regulates SREBP degradation in yeast. EMBO J. 2009 Jan 21;28(2):135-43. doi: 10.1038/emboj.2008.271. PMID:19158663 doi:http://dx.doi.org/10.1038/emboj.2008.271
2. ↑ Loenarz C, Sekirnik R, Thalhammer A, Ge W, Spivakovsky E, Mackeen MM, McDonough MA, Cockman ME, Kessler BM, Ratcliffe PJ, Wolf A, Schofield CJ. Hydroxylation of the eukaryotic ribosomal decoding center affects translational accuracy. Proc Natl Acad Sci U S A. 2014 Mar 18;111(11):4019-24. doi:, 10.1073/pnas.1311750111. Epub 2014 Feb 18. PMID:24550462 doi:http://dx.doi.org/10.1073/pnas.1311750111