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2o2i

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[[Image:2o2i.jpg|left|200px]]
 
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{{Structure
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==Crystal structure of haloalkane dehalogenase Rv2579 from Mycobacterium tuberculosis complexed with 1,3-propandiol==
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|PDB= 2o2i |SIZE=350|CAPTION= <scene name='initialview01'>2o2i</scene>, resolution 1.500&Aring;
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<StructureSection load='2o2i' size='340' side='right'caption='[[2o2i]], [[Resolution|resolution]] 1.50&Aring;' scene=''>
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|SITE=
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== Structural highlights ==
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|LIGAND= <scene name='pdbligand=BR:BROMIDE+ION'>BR</scene>, <scene name='pdbligand=PDO:1,3-PROPANDIOL'>PDO</scene>
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<table><tr><td colspan='2'>[[2o2i]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Mycobacterium_tuberculosis_H37Rv Mycobacterium tuberculosis H37Rv]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2O2I OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2O2I FirstGlance]. <br>
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|ACTIVITY= <span class='plainlinks'>[http://en.wikipedia.org/wiki/Haloalkane_dehalogenase Haloalkane dehalogenase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.8.1.5 3.8.1.5] </span>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.5&#8491;</td></tr>
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|GENE= dhaA ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=1773 Mycobacterium tuberculosis])
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=BR:BROMIDE+ION'>BR</scene>, <scene name='pdbligand=PDO:1,3-PROPANDIOL'>PDO</scene></td></tr>
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|DOMAIN=
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2o2i FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2o2i OCA], [https://pdbe.org/2o2i PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2o2i RCSB], [https://www.ebi.ac.uk/pdbsum/2o2i PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2o2i ProSAT]</span></td></tr>
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|RELATEDENTRY=[[2o2h|2O2H]]
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</table>
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|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2o2i FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2o2i OCA], [http://www.ebi.ac.uk/pdbsum/2o2i PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=2o2i RCSB]</span>
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== Function ==
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}}
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[https://www.uniprot.org/uniprot/DHAA_MYCTU DHAA_MYCTU] Catalyzes hydrolytic cleavage of carbon-halogen bonds in halogenated aliphatic compounds, leading to the formation of the corresponding primary alcohols, halide ions and protons (By similarity).[HAMAP-Rule:MF_01231]
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== Evolutionary Conservation ==
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'''Crystal structure of haloalkane dehalogenase Rv2579 from Mycobacterium tuberculosis complexed with 1,3-propandiol'''
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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==About this Structure==
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/o2/2o2i_consurf.spt"</scriptWhenChecked>
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2O2I is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Mycobacterium_tuberculosis Mycobacterium tuberculosis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2O2I OCA].
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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[[Category: Haloalkane dehalogenase]]
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<text>to colour the structure by Evolutionary Conservation</text>
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[[Category: Mycobacterium tuberculosis]]
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</jmolCheckbox>
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[[Category: Single protein]]
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2o2i ConSurf].
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[[Category: Cherney, M M.]]
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<div style="clear:both"></div>
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[[Category: Garen, C R.]]
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__TOC__
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[[Category: Hulecki, J.]]
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</StructureSection>
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[[Category: James, M N.G.]]
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[[Category: Large Structures]]
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[[Category: Mazumdar, P A.]]
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[[Category: Mycobacterium tuberculosis H37Rv]]
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[[Category: TBSGC, TB Structural Genomics Consortium.]]
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[[Category: Cherney MM]]
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[[Category: 1,3-propandiol]]
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[[Category: Garen CR]]
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[[Category: alpha/beta-hydrolase protein]]
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[[Category: Hulecki J]]
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[[Category: haloalkane dehalogenase]]
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[[Category: James MNG]]
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[[Category: mycobacterium tuberculosis]]
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[[Category: Mazumdar PA]]
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[[Category: rv2579]]
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[[Category: tb structural genomics consortium]]
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[[Category: tbsgc]]
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[[Category: x-ray crystallography]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Mar 31 04:11:50 2008''
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Current revision

Crystal structure of haloalkane dehalogenase Rv2579 from Mycobacterium tuberculosis complexed with 1,3-propandiol

PDB ID 2o2i

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