This old version of Proteopedia is provided for student assignments while the new version is undergoing repairs. Content and edits done in this old version of Proteopedia after March 1, 2026 will eventually be lost when it is retired in about June of 2026.

Apply for new accounts at the new Proteopedia. Your logins will work in both the old and new versions.


2o2v

From Proteopedia

(Difference between revisions)
Jump to: navigation, search
Current revision (10:29, 30 August 2023) (edit) (undo)
 
(10 intermediate revisions not shown.)
Line 1: Line 1:
-
[[Image:2o2v.gif|left|200px]]
 
-
{{Structure
+
==Crystal Structure of the Complex of Human Mitogen Activated Protein Kinase Kinase 5 Phox Domain (MAP2K5-phox) with Human Mitogen Activated Protein Kinase Kinase Kinase 3 (MAP3K3B-phox)==
-
|PDB= 2o2v |SIZE=350|CAPTION= <scene name='initialview01'>2o2v</scene>, resolution 1.830&Aring;
+
<StructureSection load='2o2v' size='340' side='right'caption='[[2o2v]], [[Resolution|resolution]] 1.83&Aring;' scene=''>
-
|SITE=
+
== Structural highlights ==
-
|LIGAND=
+
<table><tr><td colspan='2'>[[2o2v]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2O2V OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2O2V FirstGlance]. <br>
-
|ACTIVITY= <span class='plainlinks'>[http://en.wikipedia.org/wiki/Mitogen-activated_protein_kinase_kinase Mitogen-activated protein kinase kinase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.12.2 2.7.12.2] </span>
+
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.83&#8491;</td></tr>
-
|GENE= MAP2K5, MEK5, MKK5, PRKMK5 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens]), MAP3K3, MAPKKK3, MEKK3 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens])
+
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2o2v FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2o2v OCA], [https://pdbe.org/2o2v PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2o2v RCSB], [https://www.ebi.ac.uk/pdbsum/2o2v PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2o2v ProSAT]</span></td></tr>
-
|DOMAIN=
+
</table>
-
|RELATEDENTRY=
+
== Function ==
-
|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2o2v FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2o2v OCA], [http://www.ebi.ac.uk/pdbsum/2o2v PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=2o2v RCSB]</span>
+
[https://www.uniprot.org/uniprot/MP2K5_HUMAN MP2K5_HUMAN] Acts as a scaffold for the formation of a ternary MAP3K2/MAP3K3-MAP3K5-MAPK7 signaling complex. Activation of this pathway appears to play a critical role in protecting cells from stress-induced apoptosis, neuronal survival and cardiac development and angiogenesis.<ref>PMID:7759517</ref> <ref>PMID:9384584</ref>
-
}}
+
-
'''Crystal Structure of the Complex of Human Mitogen Activated Protein Kinase Kinase 5 Phox Domain (MAP2K5-phox) with Human Mitogen Activated Protein Kinase Kinase Kinase 3 (MAP3K3B-phox)'''
+
==See Also==
-
 
+
*[[Mitogen-activated protein kinase kinase 3D structures|Mitogen-activated protein kinase kinase 3D structures]]
-
 
+
*[[Mitogen-activated protein kinase kinase kinase|Mitogen-activated protein kinase kinase kinase]]
-
==About this Structure==
+
== References ==
-
2O2V is a [[Protein complex]] structure of sequences from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2O2V OCA].
+
<references/>
 +
__TOC__
 +
</StructureSection>
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
-
[[Category: Mitogen-activated protein kinase kinase]]
+
[[Category: Large Structures]]
-
[[Category: Protein complex]]
+
[[Category: Arrowsmith C]]
-
[[Category: Arrowsmith, C.]]
+
[[Category: Edwards A]]
-
[[Category: Delft, F von.]]
+
[[Category: Filippakopoulos P]]
-
[[Category: Edwards, A.]]
+
[[Category: Knapp S]]
-
[[Category: Filippakopoulos, P.]]
+
[[Category: Savitsky P]]
-
[[Category: Knapp, S.]]
+
[[Category: Sundstrom M]]
-
[[Category: SGC, Structural Genomics Consortium.]]
+
[[Category: Ugochukwu E]]
-
[[Category: Savitsky, P.]]
+
[[Category: Von Delft F]]
-
[[Category: Sundstrom, M.]]
+
-
[[Category: Ugochukwu, E.]]
+
-
[[Category: map kinase 5]]
+
-
[[Category: map/erk kinase kinase 3]]
+
-
[[Category: map2k5]]
+
-
[[Category: mapkkk3]]
+
-
[[Category: mek5]]
+
-
[[Category: mekk3]]
+
-
[[Category: mitogen activated protein kinase kinase 5]]
+
-
[[Category: mitogen activated protein kinase kinase kinase 3]]
+
-
[[Category: mkk5]]
+
-
[[Category: phox]]
+
-
[[Category: phox-domain]]
+
-
[[Category: prkmk5]]
+
-
[[Category: sgc]]
+
-
[[Category: structural genomic]]
+
-
[[Category: structural genomics consortium]]
+
-
 
+
-
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Mar 31 04:11:55 2008''
+

Current revision

Crystal Structure of the Complex of Human Mitogen Activated Protein Kinase Kinase 5 Phox Domain (MAP2K5-phox) with Human Mitogen Activated Protein Kinase Kinase Kinase 3 (MAP3K3B-phox)

PDB ID 2o2v

Drag the structure with the mouse to rotate

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/2o2v"
Personal tools