2o2t

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[[Image:2o2t.gif|left|200px]]
 
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{{Structure
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==The crystal structure of the 1st PDZ domain of MPDZ==
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|PDB= 2o2t |SIZE=350|CAPTION= <scene name='initialview01'>2o2t</scene>, resolution 2.70&Aring;
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<StructureSection load='2o2t' size='340' side='right'caption='[[2o2t]], [[Resolution|resolution]] 2.70&Aring;' scene=''>
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|SITE=
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== Structural highlights ==
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|LIGAND=
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<table><tr><td colspan='2'>[[2o2t]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2O2T OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2O2T FirstGlance]. <br>
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|ACTIVITY=
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.7&#8491;</td></tr>
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|GENE= MPDZ, MUPP1 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens])
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2o2t FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2o2t OCA], [https://pdbe.org/2o2t PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2o2t RCSB], [https://www.ebi.ac.uk/pdbsum/2o2t PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2o2t ProSAT]</span></td></tr>
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|DOMAIN=
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</table>
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|RELATEDENTRY=
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== Function ==
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|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2o2t FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2o2t OCA], [http://www.ebi.ac.uk/pdbsum/2o2t PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=2o2t RCSB]</span>
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[https://www.uniprot.org/uniprot/MPDZ_HUMAN MPDZ_HUMAN] Interacts with HTR2C and provokes its clustering at the cell surface (By similarity). Member of the NMDAR signaling complex that may play a role in control of AMPAR potentiation and synaptic plasticity in excitatory synapses.<ref>PMID:11150294</ref> <ref>PMID:15312654</ref>
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}}
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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'''The crystal structure of the 1st PDZ domain of MPDZ'''
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/o2/2o2t_consurf.spt"</scriptWhenChecked>
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==About this Structure==
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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2O2T is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2O2T OCA].
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2o2t ConSurf].
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<div style="clear:both"></div>
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== References ==
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<references/>
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__TOC__
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</StructureSection>
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
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[[Category: Single protein]]
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[[Category: Large Structures]]
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[[Category: Arrowsmith, C.]]
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[[Category: Arrowsmith C]]
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[[Category: Berridge, G.]]
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[[Category: Berridge G]]
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[[Category: Doyle, D A.]]
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[[Category: Doyle DA]]
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[[Category: Edwards, A.]]
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[[Category: Edwards A]]
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[[Category: Elkins, J.]]
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[[Category: Elkins J]]
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[[Category: Gileadi, C.]]
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[[Category: Gileadi C]]
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[[Category: Gorrec, F.]]
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[[Category: Gorrec F]]
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[[Category: Johansson, C.]]
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[[Category: Johansson C]]
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[[Category: Papagrigoriou, E.]]
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[[Category: Papagrigoriou E]]
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[[Category: Phillips, C.]]
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[[Category: Phillips C]]
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[[Category: Pike, A C.W.]]
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[[Category: Pike ACW]]
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[[Category: SGC, Structural Genomics Consortium.]]
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[[Category: Salah E]]
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[[Category: Salah, E.]]
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[[Category: Savitsky P]]
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[[Category: Savitsky, P.]]
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[[Category: Sundstrom M]]
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[[Category: Sundstrom, M.]]
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[[Category: Umeano C]]
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[[Category: Umeano, C.]]
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[[Category: Weigelt J]]
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[[Category: Weigelt, J.]]
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[[Category: sgc]]
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[[Category: structural genomic]]
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[[Category: structural genomics consortium]]
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[[Category: structural protein]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Mar 31 04:11:54 2008''
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Current revision

The crystal structure of the 1st PDZ domain of MPDZ

PDB ID 2o2t

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Proteopedia Page Contributors and Editors (what is this?)

OCA

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