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3iyp

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==The Interaction of Decay-accelerating Factor with Echovirus 7==
==The Interaction of Decay-accelerating Factor with Echovirus 7==
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<StructureSection load='3iyp' size='340' side='right' caption='[[3iyp]], [[Resolution|resolution]] 7.20&Aring;' scene=''>
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<SX load='3iyp' size='340' side='right' viewer='molstar' caption='[[3iyp]], [[Resolution|resolution]] 7.20&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[3iyp]] is a 5 chain structure with sequence from [http://en.wikipedia.org/wiki/E7 E7], [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] and [http://en.wikipedia.org/wiki/Human_echovirus_7 Human echovirus 7]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3IYP OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3IYP FirstGlance]. <br>
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<table><tr><td colspan='2'>[[3iyp]] is a 5 chain structure with sequence from [https://en.wikipedia.org/wiki/Echovirus_E7 Echovirus E7] and [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3IYP OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3IYP FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=DAO:LAURIC+ACID'>DAO</scene></td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Electron Microscopy, [[Resolution|Resolution]] 7.2&#8491;</td></tr>
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<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">DAF ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=46018 E7])</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=DAO:LAURIC+ACID'>DAO</scene></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3iyp FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3iyp OCA], [http://pdbe.org/3iyp PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=3iyp RCSB], [http://www.ebi.ac.uk/pdbsum/3iyp PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=3iyp ProSAT]</span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3iyp FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3iyp OCA], [https://pdbe.org/3iyp PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3iyp RCSB], [https://www.ebi.ac.uk/pdbsum/3iyp PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3iyp ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
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[[http://www.uniprot.org/uniprot/DAF_HUMAN DAF_HUMAN]] This protein recognizes C4b and C3b fragments that condense with cell-surface hydroxyl or amino groups when nascent C4b and C3b are locally generated during C4 and c3 activation. Interaction of daf with cell-associated C4b and C3b polypeptides interferes with their ability to catalyze the conversion of C2 and factor B to enzymatically active C2a and Bb and thereby prevents the formation of C4b2a and C3bBb, the amplification convertases of the complement cascade.<ref>PMID:7525274</ref>
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[https://www.uniprot.org/uniprot/Q9QP24_9ENTO Q9QP24_9ENTO]
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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</div>
</div>
<div class="pdbe-citations 3iyp" style="background-color:#fffaf0;"></div>
<div class="pdbe-citations 3iyp" style="background-color:#fffaf0;"></div>
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==See Also==
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*[[CD55|CD55]]
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*[[Virus coat proteins 3D structures|Virus coat proteins 3D structures]]
== References ==
== References ==
<references/>
<references/>
__TOC__
__TOC__
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</StructureSection>
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</SX>
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[[Category: E7]]
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[[Category: Echovirus E7]]
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
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[[Category: Human echovirus 7]]
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[[Category: Large Structures]]
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[[Category: Bator, C M]]
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[[Category: Bator CM]]
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[[Category: Bowman, V D]]
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[[Category: Bowman VD]]
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[[Category: Chipman, P R]]
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[[Category: Chipman PR]]
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[[Category: Cifuente, J O]]
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[[Category: Cifuente JO]]
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[[Category: Hafenstein, S]]
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[[Category: Hafenstein S]]
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[[Category: Harris, K G]]
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[[Category: Harris KG]]
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[[Category: Lin, F]]
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[[Category: Lin F]]
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[[Category: Medof, D E]]
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[[Category: Medof DE]]
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[[Category: Plevka, P]]
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[[Category: Plevka P]]
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[[Category: Rossmann, M G]]
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[[Category: Rossmann MG]]
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[[Category: Zhang, Y]]
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[[Category: Zhang Y]]
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[[Category: Complex]]
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[[Category: Daf]]
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[[Category: Echovirus]]
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[[Category: Icosahedral virus]]
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[[Category: Receptor]]
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[[Category: Virus]]
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Current revision

The Interaction of Decay-accelerating Factor with Echovirus 7

3iyp, resolution 7.20Å

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