2o3k

From Proteopedia

(Difference between revisions)
Jump to: navigation, search
Current revision (10:29, 30 August 2023) (edit) (undo)
 
(10 intermediate revisions not shown.)
Line 1: Line 1:
-
[[Image:2o3k.gif|left|200px]]
 
-
{{Structure
+
==Yeast Cytosine Deaminase D92E Triple Mutant bound to transition state analogue HPY==
-
|PDB= 2o3k |SIZE=350|CAPTION= <scene name='initialview01'>2o3k</scene>, resolution 2.300&Aring;
+
<StructureSection load='2o3k' size='340' side='right'caption='[[2o3k]], [[Resolution|resolution]] 2.30&Aring;' scene=''>
-
|SITE=
+
== Structural highlights ==
-
|LIGAND= <scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=HPY:4-HYDROXY-3,4-DIHYDRO-1H-PYRIMIDIN-2-ONE'>HPY</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene>
+
<table><tr><td colspan='2'>[[2o3k]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Saccharomyces_cerevisiae Saccharomyces cerevisiae]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2O3K OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2O3K FirstGlance]. <br>
-
|ACTIVITY= <span class='plainlinks'>[http://en.wikipedia.org/wiki/Cytosine_deaminase Cytosine deaminase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.5.4.1 3.5.4.1] </span>
+
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.3&#8491;</td></tr>
-
|GENE= FCY1 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=4932 Saccharomyces cerevisiae])
+
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=HPY:4-HYDROXY-3,4-DIHYDRO-1H-PYRIMIDIN-2-ONE'>HPY</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
-
|DOMAIN=
+
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2o3k FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2o3k OCA], [https://pdbe.org/2o3k PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2o3k RCSB], [https://www.ebi.ac.uk/pdbsum/2o3k PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2o3k ProSAT]</span></td></tr>
-
|RELATEDENTRY=[[1ysb|1YSB]]
+
</table>
-
|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2o3k FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2o3k OCA], [http://www.ebi.ac.uk/pdbsum/2o3k PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=2o3k RCSB]</span>
+
== Function ==
-
}}
+
[https://www.uniprot.org/uniprot/FCY1_YEAST FCY1_YEAST] Converts cytosine to uracil or 5-methylcytosine to thymine by deaminating carbon number 4.
 +
== Evolutionary Conservation ==
 +
[[Image:Consurf_key_small.gif|200px|right]]
 +
Check<jmol>
 +
<jmolCheckbox>
 +
<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/o3/2o3k_consurf.spt"</scriptWhenChecked>
 +
<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
 +
<text>to colour the structure by Evolutionary Conservation</text>
 +
</jmolCheckbox>
 +
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2o3k ConSurf].
 +
<div style="clear:both"></div>
-
'''Yeast Cytosine Deaminase D92E Triple Mutant bound to transition state analogue HPY'''
+
==See Also==
-
 
+
*[[Deaminase 3D structures|Deaminase 3D structures]]
-
 
+
__TOC__
-
==About this Structure==
+
</StructureSection>
-
2O3K is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Saccharomyces_cerevisiae Saccharomyces cerevisiae]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2O3K OCA].
+
[[Category: Large Structures]]
-
[[Category: Cytosine deaminase]]
+
[[Category: Saccharomyces cerevisiae]]
[[Category: Saccharomyces cerevisiae]]
-
[[Category: Single protein]]
+
[[Category: Korkegian AM]]
-
[[Category: Korkegian, A M.]]
+
[[Category: Stoddard BL]]
-
[[Category: Stoddard, B L.]]
+
-
[[Category: homodimer]]
+
-
[[Category: hydrolase]]
+
-
[[Category: transition state analogue]]
+
-
 
+
-
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Mar 31 04:12:13 2008''
+

Current revision

Yeast Cytosine Deaminase D92E Triple Mutant bound to transition state analogue HPY

PDB ID 2o3k

Drag the structure with the mouse to rotate

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/2o3k"
Personal tools