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| | ==MYPT1(658-714)== | | ==MYPT1(658-714)== |
| - | <StructureSection load='2kjy' size='340' side='right' caption='[[2kjy]], [[NMR_Ensembles_of_Models | 20 NMR models]]' scene=''> | + | <StructureSection load='2kjy' size='340' side='right'caption='[[2kjy]]' scene=''> |
| | == Structural highlights == | | == Structural highlights == |
| - | <table><tr><td colspan='2'>[[2kjy]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2KJY OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2KJY FirstGlance]. <br> | + | <table><tr><td colspan='2'>[[2kjy]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2KJY OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2KJY FirstGlance]. <br> |
| - | </td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">PPP1R12A, MBS, MYPT1 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr> | + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr> |
| - | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2kjy FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2kjy OCA], [http://pdbe.org/2kjy PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2kjy RCSB], [http://www.ebi.ac.uk/pdbsum/2kjy PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=2kjy ProSAT]</span></td></tr> | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2kjy FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2kjy OCA], [https://pdbe.org/2kjy PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2kjy RCSB], [https://www.ebi.ac.uk/pdbsum/2kjy PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2kjy ProSAT]</span></td></tr> |
| | </table> | | </table> |
| | == Function == | | == Function == |
| - | [[http://www.uniprot.org/uniprot/MYPT1_HUMAN MYPT1_HUMAN]] Key regulator of protein phosphatase 1C (PPP1C). Mediates binding to myosin. As part of the PPP1C complex, involved in dephosphorylation of PLK1. Capable of inhibiting HIF1AN-dependent suppression of HIF1A activity.<ref>PMID:19245366</ref> <ref>PMID:18477460</ref> <ref>PMID:20354225</ref> | + | [https://www.uniprot.org/uniprot/MYPT1_HUMAN MYPT1_HUMAN] Key regulator of protein phosphatase 1C (PPP1C). Mediates binding to myosin. As part of the PPP1C complex, involved in dephosphorylation of PLK1. Capable of inhibiting HIF1AN-dependent suppression of HIF1A activity.<ref>PMID:19245366</ref> <ref>PMID:18477460</ref> <ref>PMID:20354225</ref> |
| | == Evolutionary Conservation == | | == Evolutionary Conservation == |
| | [[Image:Consurf_key_small.gif|200px|right]] | | [[Image:Consurf_key_small.gif|200px|right]] |
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| | __TOC__ | | __TOC__ |
| | </StructureSection> | | </StructureSection> |
| - | [[Category: Human]] | + | [[Category: Homo sapiens]] |
| - | [[Category: Eto, M]] | + | [[Category: Large Structures]] |
| - | [[Category: Iwaoka, R]] | + | [[Category: Eto M]] |
| - | [[Category: Mori, S]] | + | [[Category: Iwaoka R]] |
| - | [[Category: Ohki, S]] | + | [[Category: Mori S]] |
| - | [[Category: Alternative splicing]]
| + | [[Category: Ohki S]] |
| - | [[Category: Ank repeat]]
| + | |
| - | [[Category: Cytoplasm]]
| + | |
| - | [[Category: Myosin phosphatase]]
| + | |
| - | [[Category: Mypt1]]
| + | |
| - | [[Category: Phosphoprotein]]
| + | |
| - | [[Category: Phosphorylation]]
| + | |
| - | [[Category: Polymorphism]]
| + | |
| - | [[Category: Protein phosphatase 1]]
| + | |
| - | [[Category: Signaling protein]]
| + | |
| Structural highlights
Function
MYPT1_HUMAN Key regulator of protein phosphatase 1C (PPP1C). Mediates binding to myosin. As part of the PPP1C complex, involved in dephosphorylation of PLK1. Capable of inhibiting HIF1AN-dependent suppression of HIF1A activity.[1] [2] [3]
Evolutionary Conservation
Check, as determined by ConSurfDB. You may read the explanation of the method and the full data available from ConSurf.
References
- ↑ Webb JD, Muranyi A, Pugh CW, Ratcliffe PJ, Coleman ML. MYPT1, the targeting subunit of smooth-muscle myosin phosphatase, is a substrate for the asparaginyl hydroxylase factor inhibiting hypoxia-inducible factor (FIH). Biochem J. 2009 May 13;420(2):327-33. doi: 10.1042/BJ20081905. PMID:19245366 doi:10.1042/BJ20081905
- ↑ Yamashiro S, Yamakita Y, Totsukawa G, Goto H, Kaibuchi K, Ito M, Hartshorne DJ, Matsumura F. Myosin phosphatase-targeting subunit 1 regulates mitosis by antagonizing polo-like kinase 1. Dev Cell. 2008 May;14(5):787-97. doi: 10.1016/j.devcel.2008.02.013. PMID:18477460 doi:10.1016/j.devcel.2008.02.013
- ↑ Zagorska A, Deak M, Campbell DG, Banerjee S, Hirano M, Aizawa S, Prescott AR, Alessi DR. New roles for the LKB1-NUAK pathway in controlling myosin phosphatase complexes and cell adhesion. Sci Signal. 2010 Mar 30;3(115):ra25. doi: 10.1126/scisignal.2000616. PMID:20354225 doi:http://dx.doi.org/10.1126/scisignal.2000616
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