2k9x
From Proteopedia
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==Solution structure of Urm1 from Trypanosoma brucei== | ==Solution structure of Urm1 from Trypanosoma brucei== | ||
| - | <StructureSection load='2k9x' size='340' side='right' caption='[[2k9x | + | <StructureSection load='2k9x' size='340' side='right'caption='[[2k9x]]' scene=''> |
== Structural highlights == | == Structural highlights == | ||
| - | <table><tr><td colspan='2'>[[2k9x]] is a 1 chain structure with sequence from [ | + | <table><tr><td colspan='2'>[[2k9x]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Trypanosoma_brucei Trypanosoma brucei]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2K9X OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2K9X FirstGlance]. <br> |
| - | </td></tr><tr id=' | + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr> |
| - | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[ | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2k9x FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2k9x OCA], [https://pdbe.org/2k9x PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2k9x RCSB], [https://www.ebi.ac.uk/pdbsum/2k9x PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2k9x ProSAT]</span></td></tr> |
</table> | </table> | ||
== Function == | == Function == | ||
| - | [ | + | [https://www.uniprot.org/uniprot/Q583L0_TRYB2 Q583L0_TRYB2] Acts as a sulfur carrier required for 2-thiolation of mcm(5)S(2)U at tRNA wobble positions of cytosolic tRNA(Lys), tRNA(Glu) and tRNA(Gln). Serves as sulfur donor in tRNA 2-thiolation reaction by being thiocarboxylated (-COSH) at its C-terminus by the MOCS3 homolog. The sulfur is then transferred to tRNA to form 2-thiolation of mcm(5)S(2)U. Also acts as a ubiquitin-like protein (UBL) that is covalently conjugated via an isopeptide bond to lysine residues of target proteins. The thiocarboxylated form serves as substrate for conjugation and oxidative stress specifically induces the formation of UBL-protein conjugates.[HAMAP-Rule:MF_03048] |
== Evolutionary Conservation == | == Evolutionary Conservation == | ||
[[Image:Consurf_key_small.gif|200px|right]] | [[Image:Consurf_key_small.gif|200px|right]] | ||
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__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
| - | [[Category: | + | [[Category: Large Structures]] |
| - | [[Category: | + | [[Category: Trypanosoma brucei]] |
| - | [[Category: | + | [[Category: Tu X]] |
| - | [[Category: | + | [[Category: Wang T]] |
| - | [[Category: | + | [[Category: Xu C]] |
| - | [[Category: Zhang | + | [[Category: Zhang J]] |
| - | [[Category: | + | [[Category: Zhang W]] |
| - | [[Category: | + | [[Category: Zhang X]] |
Current revision
Solution structure of Urm1 from Trypanosoma brucei
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Categories: Large Structures | Trypanosoma brucei | Tu X | Wang T | Xu C | Zhang J | Zhang W | Zhang X
