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| | ==Mouse CD3epsilon Cytoplasmic Tail== | | ==Mouse CD3epsilon Cytoplasmic Tail== |
| - | <StructureSection load='2k4f' size='340' side='right' caption='[[2k4f]], [[NMR_Ensembles_of_Models | 20 NMR models]]' scene=''> | + | <StructureSection load='2k4f' size='340' side='right'caption='[[2k4f]]' scene=''> |
| | == Structural highlights == | | == Structural highlights == |
| - | <table><tr><td colspan='2'>[[2k4f]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Lk3_transgenic_mice Lk3 transgenic mice]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2K4F OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2K4F FirstGlance]. <br> | + | <table><tr><td colspan='2'>[[2k4f]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2K4F OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2K4F FirstGlance]. <br> |
| - | </td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">Cd3e ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10090 LK3 transgenic mice])</td></tr> | + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr> |
| - | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2k4f FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2k4f OCA], [http://pdbe.org/2k4f PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2k4f RCSB], [http://www.ebi.ac.uk/pdbsum/2k4f PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=2k4f ProSAT]</span></td></tr> | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2k4f FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2k4f OCA], [https://pdbe.org/2k4f PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2k4f RCSB], [https://www.ebi.ac.uk/pdbsum/2k4f PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2k4f ProSAT]</span></td></tr> |
| | </table> | | </table> |
| | == Function == | | == Function == |
| - | [[http://www.uniprot.org/uniprot/CD3E_MOUSE CD3E_MOUSE]] The CD3 complex mediates signal transduction. | + | [https://www.uniprot.org/uniprot/CD3E_MOUSE CD3E_MOUSE] The CD3 complex mediates signal transduction. |
| | == Evolutionary Conservation == | | == Evolutionary Conservation == |
| | [[Image:Consurf_key_small.gif|200px|right]] | | [[Image:Consurf_key_small.gif|200px|right]] |
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| | ==See Also== | | ==See Also== |
| - | *[[CD3|CD3]] | + | *[[CD3 3D structures|CD3 3D structures]] |
| | == References == | | == References == |
| | <references/> | | <references/> |
| | __TOC__ | | __TOC__ |
| | </StructureSection> | | </StructureSection> |
| - | [[Category: Lk3 transgenic mice]] | + | [[Category: Large Structures]] |
| - | [[Category: Call, M E]] | + | [[Category: Mus musculus]] |
| - | [[Category: Chou, J J]] | + | [[Category: Call ME]] |
| - | [[Category: Gagnon, E E]] | + | [[Category: Chou JJ]] |
| - | [[Category: Schnell, J R]] | + | [[Category: Gagnon EE]] |
| - | [[Category: Schwieters, C D]] | + | [[Category: Schnell JR]] |
| - | [[Category: Wucherpfennig, K W]] | + | [[Category: Schwieters CD]] |
| - | [[Category: Xu, C]] | + | [[Category: Wucherpfennig KW]] |
| - | [[Category: Bicelle]]
| + | [[Category: Xu C]] |
| - | [[Category: Cd3e]]
| + | |
| - | [[Category: Immune system]]
| + | |
| - | [[Category: Immunoglobulin domain]]
| + | |
| - | [[Category: Itam]]
| + | |
| - | [[Category: Membrane]]
| + | |
| - | [[Category: Membrane bound protein]]
| + | |
| - | [[Category: Phosphoprotein]]
| + | |
| - | [[Category: Receptor]]
| + | |
| - | [[Category: Signaling protein]]
| + | |
| - | [[Category: Tcr]]
| + | |
| - | [[Category: Transmembrane]]
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| Structural highlights
Function
CD3E_MOUSE The CD3 complex mediates signal transduction.
Evolutionary Conservation
Check, as determined by ConSurfDB. You may read the explanation of the method and the full data available from ConSurf.
Publication Abstract from PubMed
Many immune system receptors signal through cytoplasmic tyrosine-based motifs (ITAMs), but how receptor ligation results in ITAM phosphorylation remains unknown. Live-cell imaging studies showed a close interaction of the CD3epsilon cytoplasmic domain of the T cell receptor (TCR) with the plasma membrane through fluorescence resonance energy transfer between a C-terminal fluorescent protein and a membrane fluorophore. Electrostatic interactions between basic CD3epsilon residues and acidic phospholipids enriched in the inner leaflet of the plasma membrane were required for binding. The nuclear magnetic resonance structure of the lipid-bound state of this cytoplasmic domain revealed deep insertion of the two key tyrosines into the hydrophobic core of the lipid bilayer. Receptor ligation thus needs to result in unbinding of the CD3epsilon ITAM from the membrane to render these tyrosines accessible to Src kinases. Sequestration of key tyrosines into the lipid bilayer represents a previously unrecognized mechanism for control of receptor activation.
Regulation of T cell receptor activation by dynamic membrane binding of the CD3epsilon cytoplasmic tyrosine-based motif.,Xu C, Gagnon E, Call ME, Schnell JR, Schwieters CD, Carman CV, Chou JJ, Wucherpfennig KW Cell. 2008 Nov 14;135(4):702-13. PMID:19013279[1]
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.
See Also
References
- ↑ Xu C, Gagnon E, Call ME, Schnell JR, Schwieters CD, Carman CV, Chou JJ, Wucherpfennig KW. Regulation of T cell receptor activation by dynamic membrane binding of the CD3epsilon cytoplasmic tyrosine-based motif. Cell. 2008 Nov 14;135(4):702-13. PMID:19013279 doi:http://dx.doi.org/S0092-8674(08)01237-3
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