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| | ==Solution structure of the domain X of measle phosphoprotein== | | ==Solution structure of the domain X of measle phosphoprotein== |
| - | <StructureSection load='2k9d' size='340' side='right' caption='[[2k9d]], [[NMR_Ensembles_of_Models | 20 NMR models]]' scene=''> | + | <StructureSection load='2k9d' size='340' side='right'caption='[[2k9d]]' scene=''> |
| | == Structural highlights == | | == Structural highlights == |
| - | <table><tr><td colspan='2'>[[2k9d]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Cell-associated_subacute_sclerosing_panencephalitis Cell-associated subacute sclerosing panencephalitis]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2K9D OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2K9D FirstGlance]. <br> | + | <table><tr><td colspan='2'>[[2k9d]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Measles_morbillivirus Measles morbillivirus]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2K9D OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2K9D FirstGlance]. <br> |
| - | </td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">P/V ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=11234 Cell-associated subacute sclerosing panencephalitis])</td></tr> | + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr> |
| - | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2k9d FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2k9d OCA], [http://pdbe.org/2k9d PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2k9d RCSB], [http://www.ebi.ac.uk/pdbsum/2k9d PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=2k9d ProSAT]</span></td></tr> | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2k9d FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2k9d OCA], [https://pdbe.org/2k9d PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2k9d RCSB], [https://www.ebi.ac.uk/pdbsum/2k9d PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2k9d ProSAT]</span></td></tr> |
| | </table> | | </table> |
| | == Function == | | == Function == |
| - | [[http://www.uniprot.org/uniprot/PHOSP_MEASE PHOSP_MEASE]] Essential component of the RNA polymerase and the nascent chain assembly complex. Also required during RNA synthesis. | + | [https://www.uniprot.org/uniprot/PHOSP_MEASE PHOSP_MEASE] Essential component of the RNA polymerase and the nascent chain assembly complex. Also required during RNA synthesis. |
| | == Evolutionary Conservation == | | == Evolutionary Conservation == |
| | [[Image:Consurf_key_small.gif|200px|right]] | | [[Image:Consurf_key_small.gif|200px|right]] |
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| | __TOC__ | | __TOC__ |
| | </StructureSection> | | </StructureSection> |
| - | [[Category: Cell-associated subacute sclerosing panencephalitis]] | + | [[Category: Large Structures]] |
| - | [[Category: Bernard, C]] | + | [[Category: Measles morbillivirus]] |
| - | [[Category: Bourhis, J M]] | + | [[Category: Bernard C]] |
| - | [[Category: Darbon, H]] | + | [[Category: Bourhis JM]] |
| - | [[Category: Gely, S]] | + | [[Category: Darbon H]] |
| - | [[Category: Longhi, S]] | + | [[Category: Gely S]] |
| - | [[Category: Measle]]
| + | [[Category: Longhi S]] |
| - | [[Category: Morbillivirus]]
| + | |
| - | [[Category: Phosphoprotein]]
| + | |
| - | [[Category: Rna editing]]
| + | |
| - | [[Category: Rna replication]]
| + | |
| - | [[Category: Viral protein]]
| + | |
| - | [[Category: X domain]]
| + | |
| Structural highlights
Function
PHOSP_MEASE Essential component of the RNA polymerase and the nascent chain assembly complex. Also required during RNA synthesis.
Evolutionary Conservation
Check, as determined by ConSurfDB. You may read the explanation of the method and the full data available from ConSurf.
Publication Abstract from PubMed
In this paper we investigate the interaction between the C-terminal domains of the measles virus phosphoprotein (XD) and nucleoprotein (N(TAIL)) by using nuclear magnetic resonance chemical shift perturbation experiments. Using both N(TAIL) constructs and peptides, we show that contrary to the conserved Box2 region (N(489-506)), the C-terminal region of N(TAIL) (N(513-525)) does not directly interact with XD, and yet affects binding to XD. We tentatively propose a model where the C-terminus of N(TAIL) would stabilize the N(TAIL)-XD complex either via a functional coupling with N(489-506) or by reducing the entropic penalty associated to the binding-coupled-to-folding process.
Interaction between the C-terminal domains of N and P proteins of measles virus investigated by NMR.,Bernard C, Gely S, Bourhis JM, Morelli X, Longhi S, Darbon H FEBS Lett. 2009 Apr 2;583(7):1084-9. Epub 2009 Mar 9. PMID:19275899[1]
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.
References
- ↑ Bernard C, Gely S, Bourhis JM, Morelli X, Longhi S, Darbon H. Interaction between the C-terminal domains of N and P proteins of measles virus investigated by NMR. FEBS Lett. 2009 Apr 2;583(7):1084-9. Epub 2009 Mar 9. PMID:19275899 doi:10.1016/j.febslet.2009.03.004
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