Isopropylmalate dehydrogenase
From Proteopedia
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== Structural highlights == | == Structural highlights == | ||
| - | <scene name='49/490899/Cv/ | + | <scene name='49/490899/Cv/11'>3-isopropylmalate dehydrogenase complex with 3-isopropylmalate, glycerol, NAD, PMSF, Mn+2 and K- ions</scene>. |
IMDH active site containing the <scene name='49/490899/Cv/9'>NAD cofactor is located between 2 subunits</scene> and contains the substrate and Mn+2 and K- ions<ref>PMID:25211160</ref>. Water molecules shown as red spheres. | IMDH active site containing the <scene name='49/490899/Cv/9'>NAD cofactor is located between 2 subunits</scene> and contains the substrate and Mn+2 and K- ions<ref>PMID:25211160</ref>. Water molecules shown as red spheres. | ||
| - | <scene name='49/490899/Cv/ | + | <scene name='49/490899/Cv/12'>MN coordination site</scene>. |
| - | <scene name='49/490899/Cv/ | + | <scene name='49/490899/Cv/13'>K coordination site</scene>. |
| - | <scene name='49/490899/Cv/ | + | <scene name='49/490899/Cv/14'>3-isopropylmalate binding site</scene>. |
| - | <scene name='49/490899/Cv/ | + | <scene name='49/490899/Cv/15'>Whole IMDH active site</scene>. |
</StructureSection> | </StructureSection> | ||
==3D structures of isopropylmalate dehydrogenase== | ==3D structures of isopropylmalate dehydrogenase== | ||
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**[[4y1p]] - IMDH + 3IPM + Mg – ''Sulfolobus acidarius''<br /> | **[[4y1p]] - IMDH + 3IPM + Mg – ''Sulfolobus acidarius''<br /> | ||
**[[5j32]] - AtIMDH + 3IPM + Mg<br /> | **[[5j32]] - AtIMDH + 3IPM + Mg<br /> | ||
| + | **[[6xxy]] - IMDH (mutant) + NAD + isobutenyl oxalylhydroxamate – ''Haemophilus influenzae''<BR /> | ||
}} | }} | ||
Current revision
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3D structures of isopropylmalate dehydrogenase
Updated on 30-August-2020
References
- ↑ Martignon S, Rossi F, Rizzi M. Expression, purification and characterisation of Haemophilus influenzae 3-isopropylmalate dehydrogenase (LeuB). Protein Pept Lett. 2007;14(8):822-7. PMID:17979826
- ↑ Pallo A, Olah J, Graczer E, Merli A, Zavodszky P, Weiss MS, Vas M. Structural and energetic basis of isopropylmalate dehydrogenase enzyme catalysis. FEBS J. 2014 Sep 11. doi: 10.1111/febs.13044. PMID:25211160 doi:http://dx.doi.org/10.1111/febs.13044
