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| - | [[Image:2jcz.gif|left|200px]]<br /> | + | #REDIRECT [[4aic]] This PDB entry is obsolete and replaced by 4aic |
| - | <applet load="2jcz" size="450" color="white" frame="true" align="right" spinBox="true"
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| - | caption="2jcz, resolution 2.05Å" />
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| - | '''X-RAY STRUCTURE OF 1-DEOXY-D-XYLULOSE 5-PHOSPHATE REDUCTOISOMERASE, DXR, RV2870C, FROM MYCOBACTERIUM TUBERCULOSIS, IN COMPLEX WITH FOSMIDOMYCIN, MANGANESE AND NADPH'''<br />
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| - | ==Overview==
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| - | Isopentenyl diphosphate is the precursor of various isoprenoids that are, essential to all living organisms. It is produced by the mevalonate, pathway in humans but by an alternate route in plants, protozoa, and many, bacteria. 1-deoxy-D-xylulose-5-phosphate reductoisomerase catalyzes the, second step of this non-mevalonate pathway, which involves an, NADPH-dependent rearrangement and reduction of 1-deoxy-D-xylulose, 5-phosphate to form 2-C-methyl-D-erythritol 4-phosphate. The use of, different pathways, combined with the reported essentiality of the enzyme, makes the reductoisomerase a highly promising target for drug design. Here, we present several high resolution structures of the Mycobacterium, tuberculosis 1-deoxy-D-xylulose-5-phosphate reductoisomerase, representing, both wild type ... [[http://ispc.weizmann.ac.il/pmbin/getpm?17491006 (full description)]]
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| - | ==About this Structure==
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| - | 2JCZ is a [[http://en.wikipedia.org/wiki/Single_protein Single protein]] structure of sequence from [[http://en.wikipedia.org/wiki/Mycobacterium_tuberculosis Mycobacterium tuberculosis]] with MN, SO4, FOM and NDP as [[http://en.wikipedia.org/wiki/ligands ligands]]. Active as [[http://en.wikipedia.org/wiki/ ]], with EC number [[http://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.1.1.267 1.1.1.267]]. Full crystallographic information is available from [[http://ispc.weizmann.ac.il/oca-bin/ocashort?id=2JCZ OCA]].
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| - | ==Reference==
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| - | Structures of Mycobacterium tuberculosis 1-deoxy-D-xylulose-5-phosphate reductoisomerase provide new insights into catalysis., Henriksson LM, Unge T, Carlsson J, Aqvist J, Mowbray SL, Jones TA, J Biol Chem. 2007 Jul 6;282(27):19905-16. Epub 2007 May 9. PMID:[http://ispc.weizmann.ac.il//pmbin/getpm?pmid=17491006 17491006]
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| - | [[Category: Mycobacterium tuberculosis]]
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| - | [[Category: Single protein]]
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| - | [[Category: Henriksson, L.M.]]
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| - | [[Category: Jones, T.A.]]
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| - | [[Category: Mowbray, S.L.]]
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| - | [[Category: Unge, T.]]
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| - | [[Category: FOM]]
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| - | [[Category: MN]]
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| - | [[Category: NDP]]
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| - | [[Category: SO4]]
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| - | [[Category: 1-deoxy-d-xylulose 5-phosphate reductoisomerase]]
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| - | [[Category: doxp/mep pathway]]
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| - | [[Category: isoprene biosynthesis]]
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| - | [[Category: metal-binding]]
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| - | [[Category: nadp]]
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| - | [[Category: oxidoreductase]]
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| - | [[Category: rv2870c]]
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| - | ''Page seeded by [http://ispc.weizmann.ac.il/oca OCA ] on Mon Oct 29 17:33:19 2007''
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