2oby

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[[Image:2oby.gif|left|200px]]
 
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{{Structure
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==Crystal structure of Human P53 inducible oxidoreductase (TP53I3,PIG3)==
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|PDB= 2oby |SIZE=350|CAPTION= <scene name='initialview01'>2oby</scene>, resolution 3.00&Aring;
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<StructureSection load='2oby' size='340' side='right'caption='[[2oby]], [[Resolution|resolution]] 3.00&Aring;' scene=''>
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|SITE=
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== Structural highlights ==
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|LIGAND= <scene name='pdbligand=NAP:NADP+NICOTINAMIDE-ADENINE-DINUCLEOTIDE+PHOSPHATE'>NAP</scene>
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<table><tr><td colspan='2'>[[2oby]] is a 5 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2OBY OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2OBY FirstGlance]. <br>
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|ACTIVITY=
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 3&#8491;</td></tr>
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|GENE= TP53I3, PIG3 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens])
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=NAP:NADP+NICOTINAMIDE-ADENINE-DINUCLEOTIDE+PHOSPHATE'>NAP</scene></td></tr>
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|DOMAIN=
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2oby FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2oby OCA], [https://pdbe.org/2oby PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2oby RCSB], [https://www.ebi.ac.uk/pdbsum/2oby PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2oby ProSAT]</span></td></tr>
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|RELATEDENTRY=
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</table>
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|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2oby FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2oby OCA], [http://www.ebi.ac.uk/pdbsum/2oby PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=2oby RCSB]</span>
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== Function ==
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}}
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[https://www.uniprot.org/uniprot/QORX_HUMAN QORX_HUMAN] May be involved in the generation of reactive oxygen species (ROS). Has low NADPH-dependent beta-naphthoquinone reductase activity, with a preference for 1,2-beta-naphthoquinone over 1,4-beta-naphthoquinone. Has low NADPH-dependent diamine reductase activity (in vitro).<ref>PMID:19349281</ref>
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== Evolutionary Conservation ==
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'''Crystal structure of Human P53 inducible oxidoreductase (TP53I3,PIG3)'''
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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==About this Structure==
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/ob/2oby_consurf.spt"</scriptWhenChecked>
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2OBY is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2OBY OCA].
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2oby ConSurf].
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<div style="clear:both"></div>
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== References ==
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<references/>
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__TOC__
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</StructureSection>
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
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[[Category: Single protein]]
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[[Category: Large Structures]]
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[[Category: Arrowsmith, C H.]]
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[[Category: Arrowsmith CH]]
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[[Category: Debreczeni, J.]]
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[[Category: Debreczeni J]]
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[[Category: Delft, F Von.]]
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[[Category: Edwards A]]
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[[Category: Edwards, A.]]
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[[Category: Farres J]]
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[[Category: Farres, J.]]
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[[Category: Fita I]]
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[[Category: Fita, I.]]
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[[Category: Gileadi O]]
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[[Category: Gileadi, O.]]
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[[Category: Haroniti A]]
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[[Category: Haroniti, A.]]
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[[Category: Johansson C]]
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[[Category: Johansson, C.]]
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[[Category: Oppermann U]]
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[[Category: Oppermann, U.]]
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[[Category: Pares X]]
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[[Category: Pares, X.]]
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[[Category: Pike ACW]]
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[[Category: Pike, A C.W.]]
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[[Category: Porte S]]
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[[Category: Porte, S.]]
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[[Category: Shafqat N]]
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[[Category: Shafqat, N.]]
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[[Category: Sundstrom M]]
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[[Category: Sundstrom, M.]]
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[[Category: Valencia E]]
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[[Category: Valencia, E.]]
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[[Category: Weigelt J]]
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[[Category: Weigelt, J.]]
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[[Category: Von Delft F]]
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[[Category: oxidoreductase]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Mar 31 04:15:35 2008''
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Current revision

Crystal structure of Human P53 inducible oxidoreductase (TP53I3,PIG3)

PDB ID 2oby

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Proteopedia Page Contributors and Editors (what is this?)

OCA

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