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2ocs

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[[Image:2ocs.gif|left|200px]]
 
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{{Structure
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==The crystal structure of the first PDZ domain of human NHERF-2 (SLC9A3R2)==
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|PDB= 2ocs |SIZE=350|CAPTION= <scene name='initialview01'>2ocs</scene>, resolution 1.50&Aring;
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<StructureSection load='2ocs' size='340' side='right'caption='[[2ocs]], [[Resolution|resolution]] 1.50&Aring;' scene=''>
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|SITE=
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== Structural highlights ==
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|LIGAND= <scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=SCN:THIOCYANATE+ION'>SCN</scene>
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<table><tr><td colspan='2'>[[2ocs]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2OCS OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2OCS FirstGlance]. <br>
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|ACTIVITY=
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.5&#8491;</td></tr>
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|GENE= SLC9A3R2, NHERF2 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens])
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=SCN:THIOCYANATE+ION'>SCN</scene></td></tr>
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|DOMAIN=
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2ocs FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2ocs OCA], [https://pdbe.org/2ocs PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2ocs RCSB], [https://www.ebi.ac.uk/pdbsum/2ocs PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2ocs ProSAT]</span></td></tr>
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|RELATEDENTRY=
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</table>
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|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2ocs FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2ocs OCA], [http://www.ebi.ac.uk/pdbsum/2ocs PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=2ocs RCSB]</span>
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== Function ==
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}}
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[https://www.uniprot.org/uniprot/NHRF2_HUMAN NHRF2_HUMAN] Scaffold protein that connects plasma membrane proteins with members of the ezrin/moesin/radixin family and thereby helps to link them to the actin cytoskeleton and to regulate their surface expression. Necessary for cAMP-mediated phosphorylation and inhibition of SLC9A3. May also act as scaffold protein in the nucleus.<ref>PMID:9096337</ref> <ref>PMID:10455146</ref>
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/oc/2ocs_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2ocs ConSurf].
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<div style="clear:both"></div>
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'''The crystal structure of the first PDZ domain of human NHERF-2 (SLC9A3R2)'''
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==See Also==
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*[[Sodium-hydrogen exchange regulatory factor 3D structures|Sodium-hydrogen exchange regulatory factor 3D structures]]
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== References ==
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==About this Structure==
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<references/>
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2OCS is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2OCS OCA].
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__TOC__
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</StructureSection>
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
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[[Category: Single protein]]
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[[Category: Large Structures]]
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[[Category: Arrowsmith, C H.]]
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[[Category: Arrowsmith CH]]
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[[Category: Berridge, G.]]
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[[Category: Berridge G]]
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[[Category: Burgess, N.]]
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[[Category: Burgess N]]
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[[Category: Doyle, D A.]]
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[[Category: Doyle DA]]
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[[Category: Edwards, A.]]
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[[Category: Edwards A]]
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[[Category: Elkins, J.]]
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[[Category: Elkins J]]
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[[Category: Gileadi, C.]]
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[[Category: Gileadi C]]
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[[Category: Gileadi, O.]]
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[[Category: Gileadi O]]
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[[Category: Gorrec, F.]]
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[[Category: Gorrec F]]
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[[Category: Papagrigoriou, E.]]
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[[Category: Papagrigoriou E]]
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[[Category: Phillips, C.]]
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[[Category: Phillips C]]
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[[Category: SGC, Structural Genomics Consortium.]]
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[[Category: Salah E]]
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[[Category: Salah, E.]]
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[[Category: Savitsky P]]
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[[Category: Savitsky, P.]]
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[[Category: Sundstrom M]]
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[[Category: Sundstrom, M.]]
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[[Category: Ugochukwu E]]
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[[Category: Ugochukwu, E.]]
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[[Category: Umeano C]]
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[[Category: Umeano, C.]]
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[[Category: Weigelt J]]
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[[Category: Weigelt, J.]]
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[[Category: sgc]]
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[[Category: structural genomic]]
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[[Category: structural genomics consortium]]
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[[Category: structural protein]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Mar 31 04:15:53 2008''
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Current revision

The crystal structure of the first PDZ domain of human NHERF-2 (SLC9A3R2)

PDB ID 2ocs

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