2km3

<StructureSection load='2km3' size='340' side='right' caption='[[2km3]], [[NMR_Ensembles_of_Models | 10 NMR models]]' scene=''>

<table><tr><td colspan='2'>[[2km3]] is a 1 chain structure. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2KM3 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2KM3 FirstGlance]. <br>

</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[143d|143d]], [[1k8p|1k8p]], [[2aqy|2aqy]], [[2gku|2gku]], [[2jsk|2jsk]], [[2jsl|2jsl]], [[2jsm|2jsm]], [[2jsq|2jsq]], [[2kf7|2kf7]], [[2kf8|2kf8]]</td></tr>

<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2km3 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2km3 OCA], [http://pdbe.org/2km3 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2km3 RCSB], [http://www.ebi.ac.uk/pdbsum/2km3 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=2km3 ProSAT]</span></td></tr>

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== Publication Abstract from PubMed ==

Short contiguous arrays of variant CTAGGG repeats in the human telomere are unstable in the male germline and somatic cells, suggesting formation of unusual structures by this repeat type. Here, we report on the structure of an intramolecular G-quadruplex formed by DNA sequences containing four human telomeric variant CTAGGG repeats in potassium solution. Our results reveal a new robust antiparallel G-quadruplex fold involving two G-tetrads sandwiched between a G.C base pair and a G.C.G.C tetrad, which could represent a new platform for drug design targeted to human telomeric DNA.

Sequence variant (CTAGGG)n in the human telomere favors a G-quadruplex structure containing a G.C.G.C tetrad.,Lim KW, Alberti P, Guedin A, Lacroix L, Riou JF, Royle NJ, Mergny JL, Phan AT Nucleic Acids Res. 2009 Oct;37(18):6239-48. Epub 2009 Aug 19. PMID:19692585<ref>PMID:19692585</ref>

From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>

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<div class="pdbe-citations 2km3" style="background-color:#fffaf0;"></div>

== References ==

<references/>

[[Category: Alberti, P]]

[[Category: Guedin, A]]

[[Category: Lacroix, L]]

[[Category: Lim, K W]]

[[Category: Mergny, J L]]

[[Category: Phan, A T]]

[[Category: Riou, J F]]

[[Category: Royle, N J]]

[[Category: Human telomere instability]]