2kym

<StructureSection load='2kym' size='340' side='right' caption='[[2kym]], [[NMR_Ensembles_of_Models | 20 NMR models]]' scene=''>

<table><tr><td colspan='2'>[[2kym]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Lodel Lodel]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2KYM OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2KYM FirstGlance]. <br>

</td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">LELG_04233 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=379508 LODEL])</td></tr>

<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2kym FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2kym OCA], [http://pdbe.org/2kym PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2kym RCSB], [http://www.ebi.ac.uk/pdbsum/2kym PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=2kym ProSAT]</span></td></tr>

[[http://www.uniprot.org/uniprot/STE20_YEAST STE20_YEAST]] MAP4K component of the MAPK pathway required for the mating pheromone response, haploid invasive growth and diploid pseudohyphal development. Links the pheromone response G-protein beta gamma subunits to downstream signaling components. Needed for mating in haploid cells, induction of a mating-specific gene FUS1, induction of mating-specific morphologies, and pheromone-induced proliferation arrest. Required for the regulation of the actin polarization and bud emergence during cell cycle in G1. Involved in the high osmolarity glycerol (HOG) response. Phosphorylates 'Thr-307' and 'Ser-302' or 'Ser-306' of STE11 and 'Ser-357' of MYO3. Phosphorylates histone H2B to form H2BS10ph during meiosis and H(2)O(2)-induced apoptosis. Its interaction with CDC42 is required for both invasive growth and the formation of pseudohyphae. Its interaction with STE4 is required for the pheromone signaling.<ref>PMID:1464311</ref> <ref>PMID:8421676</ref> <ref>PMID:7608157</ref> <ref>PMID:9003780</ref> <ref>PMID:8722766</ref> <ref>PMID:8643578</ref> <ref>PMID:9009270</ref> <ref>PMID:9388196</ref> <ref>PMID:9742399</ref> <ref>PMID:9428767</ref> <ref>PMID:10562285</ref> <ref>PMID:10837245</ref> <ref>PMID:10970855</ref> <ref>PMID:11003652</ref> <ref>PMID:11940652</ref> <ref>PMID:12686605</ref> <ref>PMID:12588977</ref> <ref>PMID:15652479</ref> <ref>PMID:15970663</ref> <ref>PMID:15743816</ref>

== References ==

<references/>

[[Category: Lodel]]

[[Category: Davidson, A R]]

[[Category: Cdc42p-interacting]]

[[Category: Scaffold]]

[[Category: Sh3 domain]]

[[Category: Sh3-ci]]

[[Category: Signaling protein]]

[[Category: Ste20p prr]]