2kze

<StructureSection load='2kze' size='340' side='right' caption='[[2kze]], [[NMR_Ensembles_of_Models | 10 NMR models]]' scene=''>

<table><tr><td colspan='2'>[[2kze]] is a 1 chain structure. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2KZE OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2KZE FirstGlance]. <br>

</td></tr><tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=DI:2-DEOXYINOSINE-5-MONOPHOSPHATE'>DI</scene></td></tr>

<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[2kzd|2kzd]], [[2a5p|2a5p]], [[2o3m|2o3m]]</td></tr>

<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2kze FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2kze OCA], [http://pdbe.org/2kze PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2kze RCSB], [http://www.ebi.ac.uk/pdbsum/2kze PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=2kze ProSAT]</span></td></tr>

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== Publication Abstract from PubMed ==

The catalytic subunit of human telomerase, hTERT, actively elongates the 3' end of the telomere in most cancer cells. The hTERT promoter, which contains many guanine-rich stretches on the same DNA strand, exhibits an exceptional potential for G-quadruplex formation. Here we show that one particular G-rich sequence in this region coexists in two G-quadruplex conformations in potassium solution: a (3 + 1) and a parallel-stranded G-quadruplexes. We present the NMR solution structures of both conformations, each comprising several robust structural elements, among which include the (3 + 1) and all-parallel G-tetrad cores, single-residue double-chain-reversal loops, and a capping A.T base pair. A combination of NMR and CD techniques, complemented with sequence modifications and variations of experimental condition, allowed us to better understand the coexistence of the two G-quadruplex conformations in equilibrium and how different structural elements conspire to favor a particular form.

Coexistence of two distinct G-quadruplex conformations in the hTERT promoter.,Lim KW, Lacroix L, Yue DJ, Lim JK, Lim JM, Phan AT J Am Chem Soc. 2010 Sep 8;132(35):12331-42. PMID:20704263<ref>PMID:20704263</ref>

From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>

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<div class="pdbe-citations 2kze" style="background-color:#fffaf0;"></div>

== References ==

<references/>

[[Category: Lacroix, L]]

[[Category: Lim, J K.C]]

[[Category: Lim, J M.W]]

[[Category: Lim, K W]]

[[Category: Phan, A T]]

[[Category: Yue, D J.E]]

[[Category: Anticancer target]]

[[Category: Telomerase inhibition]]