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| | ==NMR Structure of GzCVNH (Gibberella zeae CVNH)== | | ==NMR Structure of GzCVNH (Gibberella zeae CVNH)== |
| - | <StructureSection load='2l2f' size='340' side='right' caption='[[2l2f]], [[NMR_Ensembles_of_Models | 20 NMR models]]' scene=''> | + | <StructureSection load='2l2f' size='340' side='right'caption='[[2l2f]]' scene=''> |
| | == Structural highlights == | | == Structural highlights == |
| - | <table><tr><td colspan='2'>[[2l2f]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Fusairum_graminearum Fusairum graminearum]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2L2F OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2L2F FirstGlance]. <br> | + | <table><tr><td colspan='2'>[[2l2f]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Fusarium_graminearum Fusarium graminearum]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2L2F OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2L2F FirstGlance]. <br> |
| - | </td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2l2f FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2l2f OCA], [http://pdbe.org/2l2f PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2l2f RCSB], [http://www.ebi.ac.uk/pdbsum/2l2f PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=2l2f ProSAT]</span></td></tr> | + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr> |
| | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2l2f FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2l2f OCA], [https://pdbe.org/2l2f PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2l2f RCSB], [https://www.ebi.ac.uk/pdbsum/2l2f PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2l2f ProSAT]</span></td></tr> |
| | </table> | | </table> |
| - | <div style="background-color:#fffaf0;">
| + | == Function == |
| - | == Publication Abstract from PubMed == | + | [https://www.uniprot.org/uniprot/I1RM03_GIBZE I1RM03_GIBZE] |
| - | Members of the cyanovirin-N homolog (CVNH) lectin family are found in bacteria, fungi and plants. As part of our ongoing work on CVNH structure-function studies, we determined the high-resolution NMR solution structure of the homolog from the wheat head blight disease causing ascomycetous fungus Gibberella zeae (or Fusarium graminearum), hereafter called GzCVNH. Like cyanovirin-N (CV-N), GzCVNH comprises two tandem sequence repeats and the protein sequence exhibits 30% identity with CV-N. The overall structure is similar to those of other members of the CVNH family, with the conserved pseudo-symmetric halves of the structure, domains A and B, closely resembling recently determined structures of Tuber borchii, Neurospora crassa, and Ceratopteris richardii CVNH proteins. Although GzCVNH exhibits a similar glycan recognition profile to CV-N and specifically binds to Manalpha(1-2)Manalpha, its weak carbohydrate binding affinity to only one binding site is insufficient for conferring anti-HIV activity. Proteins 2011; (c) 2011 Wiley-Liss, Inc.
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| - | NMR solution structure of a cyanovirin homolog from wheat head blight fungus.,Matei E, Louis JM, Jee J, Gronenborn AM Proteins. 2011 Jan 18. doi: 10.1002/prot.22981. PMID:21365681<ref>PMID:21365681</ref>
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| - | From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
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| - | </div>
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| - | <div class="pdbe-citations 2l2f" style="background-color:#fffaf0;"></div>
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| - | == References ==
| + | |
| - | <references/>
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| | __TOC__ | | __TOC__ |
| | </StructureSection> | | </StructureSection> |
| - | [[Category: Fusairum graminearum]] | + | [[Category: Fusarium graminearum]] |
| - | [[Category: Gronenborn, A M]] | + | [[Category: Large Structures]] |
| - | [[Category: Jee, J G]] | + | [[Category: Gronenborn AM]] |
| - | [[Category: Louis, J M]] | + | [[Category: Jee JG]] |
| - | [[Category: Matei, E]] | + | [[Category: Louis JM]] |
| - | [[Category: Carbohydrate binding protein]] | + | [[Category: Matei E]] |
| - | [[Category: Cyanovirin-n homolog]]
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| - | [[Category: Lectin]]
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| - | [[Category: Sugar binding protein]]
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