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2l1u
From Proteopedia
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==Structure-Functional Analysis of Mammalian MsrB2 protein== | ==Structure-Functional Analysis of Mammalian MsrB2 protein== | ||
| - | <StructureSection load='2l1u' size='340' side='right' caption='[[2l1u | + | <StructureSection load='2l1u' size='340' side='right'caption='[[2l1u]]' scene=''> |
== Structural highlights == | == Structural highlights == | ||
| - | <table><tr><td colspan='2'>[[2l1u]] is a 1 chain structure with sequence from [ | + | <table><tr><td colspan='2'>[[2l1u]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2L1U OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2L1U FirstGlance]. <br> |
| - | </td></tr><tr id=' | + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr> |
| - | <tr id=' | + | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr> |
| - | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[ | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2l1u FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2l1u OCA], [https://pdbe.org/2l1u PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2l1u RCSB], [https://www.ebi.ac.uk/pdbsum/2l1u PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2l1u ProSAT]</span></td></tr> |
</table> | </table> | ||
== Function == | == Function == | ||
| - | [ | + | [https://www.uniprot.org/uniprot/MSRB2_MOUSE MSRB2_MOUSE] Methionine-sulfoxide reductase that specifically reduces methionine (R)-sulfoxide back to methionine. While in many cases, methionine oxidation is the result of random oxidation following oxidative stress, methionine oxidation is also a post-translational modification that takes place on specific residue. Upon oxidative stress, may play a role in the preservation of mitochondrial integrity by decreasing the intracellular reactive oxygen species build-up through its scavenging role, hence contributing to cell survival and protein maintenance.<ref>PMID:14699060</ref> <ref>PMID:23911929</ref> |
== Evolutionary Conservation == | == Evolutionary Conservation == | ||
[[Image:Consurf_key_small.gif|200px|right]] | [[Image:Consurf_key_small.gif|200px|right]] | ||
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__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
| - | [[Category: | + | [[Category: Large Structures]] |
| - | [[Category: Aachmann | + | [[Category: Mus musculus]] |
| - | [[Category: Conte | + | [[Category: Aachmann FL]] |
| - | [[Category: Dikiy | + | [[Category: Del Conte R]] |
| - | [[Category: Gladyshev | + | [[Category: Dikiy A]] |
| - | [[Category: Kim | + | [[Category: Gladyshev VN]] |
| - | [[Category: Kwak | + | [[Category: Kim H]] |
| - | + | [[Category: Kwak G]] | |
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| - | + | ||
Current revision
Structure-Functional Analysis of Mammalian MsrB2 protein
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Categories: Large Structures | Mus musculus | Aachmann FL | Del Conte R | Dikiy A | Gladyshev VN | Kim H | Kwak G
