2kvd
From Proteopedia
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==Mesencephalic astrocyte-derived neurotrophic factor (MANF)== | ==Mesencephalic astrocyte-derived neurotrophic factor (MANF)== | ||
| - | <StructureSection load='2kvd' size='340' side='right' caption='[[2kvd | + | <StructureSection load='2kvd' size='340' side='right'caption='[[2kvd]]' scene=''> |
== Structural highlights == | == Structural highlights == | ||
| - | <table><tr><td colspan='2'>[[2kvd]] is a 1 chain structure with sequence from [ | + | <table><tr><td colspan='2'>[[2kvd]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2KVD OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2KVD FirstGlance]. <br> |
| - | </td></tr><tr id=' | + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR, 15 models</td></tr> |
| - | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2kvd FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2kvd OCA], [https://pdbe.org/2kvd PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2kvd RCSB], [https://www.ebi.ac.uk/pdbsum/2kvd PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2kvd ProSAT]</span></td></tr> | |
| - | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[ | + | |
</table> | </table> | ||
| - | == Disease == | ||
| - | [[http://www.uniprot.org/uniprot/MANF_HUMAN MANF_HUMAN]] Familial pancreatic carcinoma. | ||
| - | == Function == | ||
| - | [[http://www.uniprot.org/uniprot/MANF_HUMAN MANF_HUMAN]] Selectively promotes the survival of dopaminergic neurons of the ventral mid-brain. Modulates GABAergic transmission to the dopaminergic neurons of the substantia nigra. Enhances spontaneous, as well as evoked, GABAergic inhibitory postsynaptic currents in dopaminergic neurons (By similarity). Inhibits cell proliferation and endoplasmic reticulum (ER) stress-induced cell death.<ref>PMID:12794311</ref> <ref>PMID:18561914</ref> | ||
<div style="background-color:#fffaf0;"> | <div style="background-color:#fffaf0;"> | ||
== Publication Abstract from PubMed == | == Publication Abstract from PubMed == | ||
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__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
| - | [[Category: | + | [[Category: Homo sapiens]] |
| - | [[Category: Hellman | + | [[Category: Large Structures]] |
| - | [[Category: Peranen | + | [[Category: Hellman MH]] |
| - | [[Category: Permi | + | [[Category: Peranen J]] |
| - | [[Category: Saarma | + | [[Category: Permi P]] |
| - | + | [[Category: Saarma M]] | |
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Current revision
Mesencephalic astrocyte-derived neurotrophic factor (MANF)
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