6ac9

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m (Protected "6ac9" [edit=sysop:move=sysop])
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'''Unreleased structure'''
 
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The entry 6ac9 is ON HOLD
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==Crystal structure of human Vaccinia-related kinase 1 (VRK1) in complex with AMP-PNP==
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<StructureSection load='6ac9' size='340' side='right'caption='[[6ac9]], [[Resolution|resolution]] 2.07&Aring;' scene=''>
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== Structural highlights ==
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<table><tr><td colspan='2'>[[6ac9]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6AC9 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6AC9 FirstGlance]. <br>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.07&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ANP:PHOSPHOAMINOPHOSPHONIC+ACID-ADENYLATE+ESTER'>ANP</scene>, <scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=PG4:TETRAETHYLENE+GLYCOL'>PG4</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6ac9 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6ac9 OCA], [https://pdbe.org/6ac9 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6ac9 RCSB], [https://www.ebi.ac.uk/pdbsum/6ac9 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6ac9 ProSAT]</span></td></tr>
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</table>
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== Disease ==
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[https://www.uniprot.org/uniprot/VRK1_HUMAN VRK1_HUMAN] Pontocerebellar hypoplasia type 1. The disease is caused by mutations affecting the gene represented in this entry.
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== Function ==
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[https://www.uniprot.org/uniprot/VRK1_HUMAN VRK1_HUMAN] Serine/threonine kinase involved in Golgi disassembly during the cell cycle: following phosphorylation by PLK3 during mitosis, required to induce Golgi fragmentation. Acts by mediating phosphorylation of downstream target protein. Phosphorylates 'Thr-18' of p53/TP53 and may thereby prevent the interaction between p53/TP53 and MDM2. Phosphorylates casein and histone H3. Phosphorylates BANF1: disrupts its ability to bind DNA, reduces its binding to LEM domain-containing proteins and causes its relocalization from the nucleus to the cytoplasm. Phosphorylates ATF2 which activates its transcriptional activity.<ref>PMID:10951572</ref> <ref>PMID:14645249</ref> <ref>PMID:15105425</ref> <ref>PMID:16495336</ref> <ref>PMID:18617507</ref> <ref>PMID:19103756</ref>
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Authors: Ngow, Y.S., Sreekanth, R., Yoon, H.S.
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==See Also==
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*[[Serine/threonine protein kinase 3D structures|Serine/threonine protein kinase 3D structures]]
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Description: Crystal structure of human Vaccinia-related kinase 1 (VRK1) in complex with AMP-PNP
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== References ==
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[[Category: Unreleased Structures]]
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<references/>
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[[Category: Sreekanth, R]]
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__TOC__
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[[Category: Ngow, Y.S]]
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</StructureSection>
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[[Category: Yoon, H.S]]
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[[Category: Homo sapiens]]
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[[Category: Large Structures]]
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[[Category: Ngow YS]]
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[[Category: Sreekanth R]]
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[[Category: Yoon HS]]

Current revision

Crystal structure of human Vaccinia-related kinase 1 (VRK1) in complex with AMP-PNP

PDB ID 6ac9

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