6e68
From Proteopedia
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| - | '''Unreleased structure''' | ||
| - | + | ==NAMPT co-crystal with inhibitor compound 2== | |
| + | <StructureSection load='6e68' size='340' side='right'caption='[[6e68]], [[Resolution|resolution]] 1.50Å' scene=''> | ||
| + | == Structural highlights == | ||
| + | <table><tr><td colspan='2'>[[6e68]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6E68 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6E68 FirstGlance]. <br> | ||
| + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.5Å</td></tr> | ||
| + | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=HVM:(2E)-N-{4-[1-(3-aminobenzene-1-carbonyl)piperidin-4-yl]butyl}-3-(pyridin-3-yl)prop-2-enamide'>HVM</scene>, <scene name='pdbligand=PO4:PHOSPHATE+ION'>PO4</scene></td></tr> | ||
| + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6e68 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6e68 OCA], [https://pdbe.org/6e68 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6e68 RCSB], [https://www.ebi.ac.uk/pdbsum/6e68 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6e68 ProSAT]</span></td></tr> | ||
| + | </table> | ||
| + | == Function == | ||
| + | [https://www.uniprot.org/uniprot/NAMPT_HUMAN NAMPT_HUMAN] Catalyzes the condensation of nicotinamide with 5-phosphoribosyl-1-pyrophosphate to yield nicotinamide mononucleotide, an intermediate in the biosynthesis of NAD. It is the rate limiting component in the mammalian NAD biosynthesis pathway (By similarity). | ||
| - | + | ==See Also== | |
| - | + | *[[Phosphoribosyltransferase 3D structures|Phosphoribosyltransferase 3D structures]] | |
| - | + | __TOC__ | |
| - | [[Category: | + | </StructureSection> |
| - | [[Category: Neumann | + | [[Category: Homo sapiens]] |
| - | [[Category: Waight | + | [[Category: Large Structures]] |
| + | [[Category: Neumann CS]] | ||
| + | [[Category: Waight AB]] | ||
Current revision
NAMPT co-crystal with inhibitor compound 2
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