6e7b
From Proteopedia
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| - | '''Unreleased structure''' | ||
| - | The entry | + | ==13-pf 3-start GMPCPP-human alpha1B/beta3 microtubules== |
| + | <SX load='6e7b' size='340' side='right' viewer='molstar' caption='[[6e7b]], [[Resolution|resolution]] 3.50Å' scene=''> | ||
| + | == Structural highlights == | ||
| + | <table><tr><td colspan='2'>[[6e7b]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6E7B OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6E7B FirstGlance]. <br> | ||
| + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Electron Microscopy, [[Resolution|Resolution]] 3.5Å</td></tr> | ||
| + | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=G2P:PHOSPHOMETHYLPHOSPHONIC+ACID+GUANYLATE+ESTER'>G2P</scene>, <scene name='pdbligand=GTP:GUANOSINE-5-TRIPHOSPHATE'>GTP</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr> | ||
| + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6e7b FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6e7b OCA], [https://pdbe.org/6e7b PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6e7b RCSB], [https://www.ebi.ac.uk/pdbsum/6e7b PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6e7b ProSAT]</span></td></tr> | ||
| + | </table> | ||
| + | == Disease == | ||
| + | [https://www.uniprot.org/uniprot/TBB3_HUMAN TBB3_HUMAN] Congenital fibrosis of extraocular muscles;Cortical dysgenesis with pontocerebellar hypoplasia due to TUBB3 mutation. The disease is caused by mutations affecting the gene represented in this entry. The disease is caused by mutations affecting the gene represented in this entry. | ||
| + | == Function == | ||
| + | [https://www.uniprot.org/uniprot/TBB3_HUMAN TBB3_HUMAN] Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha chain. TUBB3 plays a critical role in proper axon guidance and mantainance.<ref>PMID:20074521</ref> | ||
| - | + | ==See Also== | |
| - | + | *[[Tubulin 3D Structures|Tubulin 3D Structures]] | |
| - | + | == References == | |
| - | [[Category: | + | <references/> |
| - | [[Category: Alushin | + | __TOC__ |
| - | [[Category: | + | </SX> |
| - | [[Category: | + | [[Category: Homo sapiens]] |
| + | [[Category: Large Structures]] | ||
| + | [[Category: Alushin GM]] | ||
| + | [[Category: Kapoor TM]] | ||
| + | [[Category: Ti SC]] | ||
Current revision
13-pf 3-start GMPCPP-human alpha1B/beta3 microtubules
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