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5owc

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==Indole-2 carboxamides as selective secreted phospholipase A2 type X (sPLA2-X) inhibitors==
==Indole-2 carboxamides as selective secreted phospholipase A2 type X (sPLA2-X) inhibitors==
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<StructureSection load='5owc' size='340' side='right' caption='[[5owc]], [[Resolution|resolution]] 1.75&Aring;' scene=''>
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<StructureSection load='5owc' size='340' side='right'caption='[[5owc]], [[Resolution|resolution]] 1.75&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[5owc]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5OWC OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5OWC FirstGlance]. <br>
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<table><tr><td colspan='2'>[[5owc]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5OWC OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5OWC FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=AYZ:3-[3-[2-aminocarbonyl-6-(trifluoromethyloxy)indol-1-yl]phenyl]propanoic+acid'>AYZ</scene>, <scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=DMS:DIMETHYL+SULFOXIDE'>DMS</scene>, <scene name='pdbligand=PEG:DI(HYDROXYETHYL)ETHER'>PEG</scene></td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.75&#8491;</td></tr>
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<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[5ow8|5ow8]]</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=AYZ:3-[3-[2-aminocarbonyl-6-(trifluoromethyloxy)indol-1-yl]phenyl]propanoic+acid'>AYZ</scene>, <scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=DMS:DIMETHYL+SULFOXIDE'>DMS</scene>, <scene name='pdbligand=PEG:DI(HYDROXYETHYL)ETHER'>PEG</scene></td></tr>
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<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Phospholipase_A(2) Phospholipase A(2)], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.1.1.4 3.1.1.4] </span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5owc FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5owc OCA], [https://pdbe.org/5owc PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5owc RCSB], [https://www.ebi.ac.uk/pdbsum/5owc PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5owc ProSAT]</span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5owc FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5owc OCA], [http://pdbe.org/5owc PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5owc RCSB], [http://www.ebi.ac.uk/pdbsum/5owc PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5owc ProSAT]</span></td></tr>
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</table>
</table>
== Function ==
== Function ==
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[[http://www.uniprot.org/uniprot/PA2GX_HUMAN PA2GX_HUMAN]] PA2 catalyzes the calcium-dependent hydrolysis of the 2-acyl groups in 3-sn-phosphoglycerides. Has a powerful potency for releasing arachidonic acid from cell membrane phospholipids. Prefers phosphatidylethanolamine and phosphatidylcholine liposomes to those of phosphatidylserine.
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[https://www.uniprot.org/uniprot/PA2GX_HUMAN PA2GX_HUMAN] PA2 catalyzes the calcium-dependent hydrolysis of the 2-acyl groups in 3-sn-phosphoglycerides. Has a powerful potency for releasing arachidonic acid from cell membrane phospholipids. Prefers phosphatidylethanolamine and phosphatidylcholine liposomes to those of phosphatidylserine.
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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</div>
</div>
<div class="pdbe-citations 5owc" style="background-color:#fffaf0;"></div>
<div class="pdbe-citations 5owc" style="background-color:#fffaf0;"></div>
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==See Also==
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*[[Phospholipase A2 3D structures|Phospholipase A2 3D structures]]
== References ==
== References ==
<references/>
<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Bodin, C]]
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[[Category: Homo sapiens]]
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[[Category: Knerr, L]]
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[[Category: Large Structures]]
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[[Category: Pettersen, D]]
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[[Category: Bodin C]]
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[[Category: Roth, R G]]
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[[Category: Knerr L]]
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[[Category: Sandmark, J S]]
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[[Category: Pettersen D]]
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[[Category: Inhibitor]]
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[[Category: Roth RG]]
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[[Category: Lipid binding protein]]
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[[Category: Sandmark JS]]
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[[Category: Phospholipase]]
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[[Category: Secreted]]
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Current revision

Indole-2 carboxamides as selective secreted phospholipase A2 type X (sPLA2-X) inhibitors

PDB ID 5owc

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