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6c94

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==Structure Of Cytochrome P450 4B1 (CYP4B1) Complexed with the Inhibitor HET0016==
==Structure Of Cytochrome P450 4B1 (CYP4B1) Complexed with the Inhibitor HET0016==
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<StructureSection load='6c94' size='340' side='right' caption='[[6c94]], [[Resolution|resolution]] 2.72&Aring;' scene=''>
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<StructureSection load='6c94' size='340' side='right'caption='[[6c94]], [[Resolution|resolution]] 2.72&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[6c94]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/European_rabbit European rabbit]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6C94 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6C94 FirstGlance]. <br>
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<table><tr><td colspan='2'>[[6c94]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Oryctolagus_cuniculus Oryctolagus cuniculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6C94 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6C94 FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=HEM:PROTOPORPHYRIN+IX+CONTAINING+FE'>HEM</scene>, <scene name='pdbligand=V16:N-(4-butyl-2-methylphenyl)-N-hydroxyimidoformamide'>V16</scene></td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.72&#8491;</td></tr>
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<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[5t6q|5t6q]]</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=HEM:PROTOPORPHYRIN+IX+CONTAINING+FE'>HEM</scene>, <scene name='pdbligand=V16:N-(4-butyl-2-methylphenyl)-N-hydroxyimidoformamide'>V16</scene></td></tr>
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<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">CYP4B1 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9986 European rabbit])</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6c94 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6c94 OCA], [https://pdbe.org/6c94 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6c94 RCSB], [https://www.ebi.ac.uk/pdbsum/6c94 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6c94 ProSAT]</span></td></tr>
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<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Unspecific_monooxygenase Unspecific monooxygenase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.14.14.1 1.14.14.1] </span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6c94 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6c94 OCA], [http://pdbe.org/6c94 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6c94 RCSB], [http://www.ebi.ac.uk/pdbsum/6c94 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6c94 ProSAT]</span></td></tr>
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</table>
</table>
== Function ==
== Function ==
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[[http://www.uniprot.org/uniprot/CP4B1_RABIT CP4B1_RABIT]] Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It oxidizes a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics.
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[https://www.uniprot.org/uniprot/CP4B1_RABIT CP4B1_RABIT] Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It oxidizes a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics.
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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</div>
</div>
<div class="pdbe-citations 6c94" style="background-color:#fffaf0;"></div>
<div class="pdbe-citations 6c94" style="background-color:#fffaf0;"></div>
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==See Also==
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*[[Cytochrome P450 3D structures|Cytochrome P450 3D structures]]
== References ==
== References ==
<references/>
<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: European rabbit]]
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[[Category: Large Structures]]
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[[Category: Unspecific monooxygenase]]
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[[Category: Oryctolagus cuniculus]]
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[[Category: Hsu, M H]]
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[[Category: Hsu M-H]]
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[[Category: Johnson, E F]]
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[[Category: Johnson EF]]
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[[Category: Cyp4b1]]
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[[Category: Cytochrome p450]]
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[[Category: Fatty acid omega-hydroxylase]]
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[[Category: Het0016]]
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[[Category: Inhibitor]]
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[[Category: Oxidoreductase]]
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[[Category: Oxidoreductase-inhibitor complex]]
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Current revision

Structure Of Cytochrome P450 4B1 (CYP4B1) Complexed with the Inhibitor HET0016

PDB ID 6c94

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