2lbv

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==Siderocalin Q83 reveals a dual ligand binding mode==
==Siderocalin Q83 reveals a dual ligand binding mode==
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<StructureSection load='2lbv' size='340' side='right' caption='[[2lbv]], [[NMR_Ensembles_of_Models | 20 NMR models]]' scene=''>
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<StructureSection load='2lbv' size='340' side='right'caption='[[2lbv]]' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[2lbv]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Cotja Cotja]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2LBV OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2LBV FirstGlance]. <br>
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<table><tr><td colspan='2'>[[2lbv]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Coturnix_japonica Coturnix japonica]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2LBV OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2LBV FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ACD:ARACHIDONIC+ACID'>ACD</scene>, <scene name='pdbligand=EB4:N,N,N-[(3S,7S,11S)-2,6,10-TRIOXO-1,5,9-TRIOXACYCLODODECANE-3,7,11-TRIYL]TRIS(2,3-DIHYDROXYBENZAMIDE)'>EB4</scene>, <scene name='pdbligand=GA:GALLIUM+(III)+ION'>GA</scene></td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR, 20 models</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2lbv FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2lbv OCA], [http://pdbe.org/2lbv PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2lbv RCSB], [http://www.ebi.ac.uk/pdbsum/2lbv PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=2lbv ProSAT]</span></td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ACD:ARACHIDONIC+ACID'>ACD</scene>, <scene name='pdbligand=EB4:N,N,N-[(3S,7S,11S)-2,6,10-TRIOXO-1,5,9-TRIOXACYCLODODECANE-3,7,11-TRIYL]TRIS(2,3-DIHYDROXYBENZAMIDE)'>EB4</scene>, <scene name='pdbligand=GA:GALLIUM+(III)+ION'>GA</scene></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2lbv FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2lbv OCA], [https://pdbe.org/2lbv PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2lbv RCSB], [https://www.ebi.ac.uk/pdbsum/2lbv PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2lbv ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
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[[http://www.uniprot.org/uniprot/EXFAB_COTJA EXFAB_COTJA]] Siderocalin-like lipocalin tightly binding a variety of bacterial ferric siderophores, also binds long-chain unsaturated fatty acids such as linoleic acid, oleic acid, arachidonic acid and, with a lower affinity, long chain saturated fatty acids such as steraic acid. May act as an antibacterial factor, through dual ligand specificity, both as a siderophore-sequestrating molecule and a lysophosphatidic acid (LPA) sensor.<ref>PMID:20826777</ref> <ref>PMID:21951132</ref>
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[https://www.uniprot.org/uniprot/EXFAB_COTJA EXFAB_COTJA] Siderocalin-like lipocalin tightly binding a variety of bacterial ferric siderophores, also binds long-chain unsaturated fatty acids such as linoleic acid, oleic acid, arachidonic acid and, with a lower affinity, long chain saturated fatty acids such as steraic acid. May act as an antibacterial factor, through dual ligand specificity, both as a siderophore-sequestrating molecule and a lysophosphatidic acid (LPA) sensor.<ref>PMID:20826777</ref> <ref>PMID:21951132</ref>
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<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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==See Also==
==See Also==
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*[[Siderocalin|Siderocalin]]
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*[[Siderocalin 3D structures|Siderocalin 3D structures]]
== References ==
== References ==
<references/>
<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Cotja]]
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[[Category: Coturnix japonica]]
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[[Category: Bister, K]]
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[[Category: Large Structures]]
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[[Category: Coudevylle, N]]
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[[Category: Bister K]]
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[[Category: Geist, L]]
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[[Category: Coudevylle N]]
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[[Category: Hoetzinger, M]]
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[[Category: Geist L]]
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[[Category: Konrat, R]]
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[[Category: Hoetzinger M]]
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[[Category: Kontaxis, G]]
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[[Category: Konrat R]]
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[[Category: Arachidonic acid]]
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[[Category: Kontaxis G]]
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[[Category: Enterobactin]]
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[[Category: Lipid transport]]
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[[Category: Lipocalin]]
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[[Category: Siderocalin]]
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Current revision

Siderocalin Q83 reveals a dual ligand binding mode

PDB ID 2lbv

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