2l8i
From Proteopedia
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==A biocompatible backbone modification? - Structure and dynamics of a triazole-linked DNA duplex== | ==A biocompatible backbone modification? - Structure and dynamics of a triazole-linked DNA duplex== | ||
| - | <StructureSection load='2l8i' size='340' side='right' caption='[[2l8i | + | <StructureSection load='2l8i' size='340' side='right'caption='[[2l8i]]' scene=''> |
== Structural highlights == | == Structural highlights == | ||
| - | <table><tr><td colspan='2'>[[2l8i]] is a 2 chain structure. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2L8I OCA]. For a <b>guided tour on the structure components</b> use [ | + | <table><tr><td colspan='2'>[[2l8i]] is a 2 chain structure. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2L8I OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2L8I FirstGlance]. <br> |
| - | </td></tr><tr id=' | + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr> |
| - | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[ | + | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=2L8:[(2R,3S,5R)-3-[(1-{[(2R,3S,5R)-3-hydroxy-5-(5-methyl-2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)tetrahydrofuran-2-yl]methyl}-1H-1,2,3-triazol-4-yl)methoxy]-5-(5-methyl-2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)tetrahydrofuran-2-yl]methyl+dihydrogen+phosphate'>2L8</scene></td></tr> |
| + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2l8i FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2l8i OCA], [https://pdbe.org/2l8i PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2l8i RCSB], [https://www.ebi.ac.uk/pdbsum/2l8i PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2l8i ProSAT]</span></td></tr> | ||
</table> | </table> | ||
| - | <div style="background-color:#fffaf0;"> | ||
| - | == Publication Abstract from PubMed == | ||
| - | Blending in: A triazole-modified DNA duplex is perturbed in structure and dynamics, but this is delocalized over five base pairs. The conformation remains B-DNA and hydrogen bonds between the DNA phosphate oxygen and polymerases can be mimicked by the triazole nitrogen. The results explain the surprising biocompatibility of triazole-linked DNA. | ||
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| - | Structure and Dynamics of Triazole-Linked DNA: Biocompatibility Explained.,Dallmann A, El-Sagheer AH, Dehmel L, Mugge C, Griesinger C, Ernsting NP, Brown T Chemistry. 2011 Dec 23;17(52):14714-7. doi: 10.1002/chem.201102979. Epub, 2011 Nov 30. PMID:22131102<ref>PMID:22131102</ref> | ||
| - | |||
| - | From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br> | ||
| - | </div> | ||
| - | <div class="pdbe-citations 2l8i" style="background-color:#fffaf0;"></div> | ||
| - | == References == | ||
| - | <references/> | ||
__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
| - | [[Category: Brown | + | [[Category: Large Structures]] |
| - | [[Category: Dehmel | + | [[Category: Brown T]] |
| - | [[Category: El-Sagheer | + | [[Category: Dehmel L]] |
| - | [[Category: Ernsting | + | [[Category: El-Sagheer A]] |
| - | [[Category: Griesinger | + | [[Category: Ernsting N]] |
| - | [[Category: Mugge | + | [[Category: Griesinger C]] |
| - | + | [[Category: Mugge C]] | |
Current revision
A biocompatible backbone modification? - Structure and dynamics of a triazole-linked DNA duplex
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