2l6i

<StructureSection load='2l6i' size='340' side='right' caption='[[2l6i]], [[NMR_Ensembles_of_Models | 27 NMR models]]' scene=''>

<table><tr><td colspan='2'>[[2l6i]] is a 1 chain structure. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2L6I OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2L6I FirstGlance]. <br>

</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2l6i FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2l6i OCA], [http://pdbe.org/2l6i PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2l6i RCSB], [http://www.ebi.ac.uk/pdbsum/2l6i PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=2l6i ProSAT]</span></td></tr>

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== Publication Abstract from PubMed ==

The transcription and replication of the severe acute respiratory syndrome (SARS) coronavirus (SARS-CoV) is regulated by specific viral genome sequences within 5'- and 3'-untranslated regions (5'-UTR and 3'-UTR). Here we report the solution structure of 5'-UTR derived stem-loop 2 (SL2) of SARS-CoV determined by NMR spectroscopy. The highly conserved pentaloop of SL2 is stacked on 5-bp stem and adopts a canonical CUYG tetraloop fold with the 3' nucleotide (U51) flipped out of the stack. The significance of this structure in the context of a previous mutagenesis analysis of SL2 function in replication of the related group 2 coronavirus, mouse hepatitis virus, is discussed.

The solution structure of coronaviral stem-loop 2 (SL2) reveals a canonical CUYG tetraloop fold.,Lee CW, Li L, Giedroc DP FEBS Lett. 2011 Mar 4. PMID:21382373<ref>PMID:21382373</ref>

From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>

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<div class="pdbe-citations 2l6i" style="background-color:#fffaf0;"></div>

== References ==

<references/>

[[Category: Giedroc, D P]]

[[Category: Lee, C]]

[[Category: Li, L]]

[[Category: Coronavirus]]

[[Category: Severe acute respiratory syndrome]]