2lnb

<StructureSection load='2lnb' size='340' side='right' caption='[[2lnb]], [[NMR_Ensembles_of_Models | 20 NMR models]]' scene=''>

<table><tr><td colspan='2'>[[2lnb]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2LNB OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2LNB FirstGlance]. <br>

</td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">C20orf183, DLM1, ZBP1 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>

<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2lnb FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2lnb OCA], [http://pdbe.org/2lnb PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2lnb RCSB], [http://www.ebi.ac.uk/pdbsum/2lnb PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=2lnb ProSAT]</span></td></tr>

[[http://www.uniprot.org/uniprot/ZBP1_HUMAN ZBP1_HUMAN]] Participates in the detection by the host's innate immune system of DNA from viral, bacterial or even host origin. Plays a role in host defense against tumors and pathogens. Acts as a cytoplasmic DNA sensor which, when activated, induces the recruitment of TBK1 and IRF3 to its C-terminal region and activates the downstream interferon regulatory factor (IRF) and NF-kappa B transcription factors, leading to type-I interferon production. ZBP1-induced NF-kappaB activation probably involves the recruitment of the RHIM containing kinases RIPK1 and RIPK3 (By similarity).

[[Category: Human]]

[[Category: Acton, T B]]

[[Category: Everett, J K]]

[[Category: Hamilton, K]]

[[Category: Kennedy, M A]]

[[Category: Kohan, E]]

[[Category: Montelione, G T]]

[[Category: Structural genomic]]

[[Category: Ramelot, T A]]

[[Category: Wang, D]]

[[Category: Xiao, R]]

[[Category: Yang, Y]]

[[Category: Psi-biology]]