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| | ==Solution Structure of the Target Recognition Domain of Zoocin A== | | ==Solution Structure of the Target Recognition Domain of Zoocin A== |
| - | <StructureSection load='2ls0' size='340' side='right' caption='[[2ls0]], [[NMR_Ensembles_of_Models | 10 NMR models]]' scene=''> | + | <StructureSection load='2ls0' size='340' side='right'caption='[[2ls0]]' scene=''> |
| | == Structural highlights == | | == Structural highlights == |
| - | <table><tr><td colspan='2'>[[2ls0]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/"animal_pyogenes,_type_a"_edwards_1934 "animal pyogenes, type a" edwards 1934]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2LS0 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2LS0 FirstGlance]. <br> | + | <table><tr><td colspan='2'>[[2ls0]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Streptococcus_equi_subsp._zooepidemicus Streptococcus equi subsp. zooepidemicus]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2LS0 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2LS0 FirstGlance]. <br> |
| - | </td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">zooA ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=40041 "Animal pyogenes, type A" Edwards 1934])</td></tr> | + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr> |
| - | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2ls0 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2ls0 OCA], [http://pdbe.org/2ls0 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2ls0 RCSB], [http://www.ebi.ac.uk/pdbsum/2ls0 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=2ls0 ProSAT]</span></td></tr> | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2ls0 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2ls0 OCA], [https://pdbe.org/2ls0 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2ls0 RCSB], [https://www.ebi.ac.uk/pdbsum/2ls0 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2ls0 ProSAT]</span></td></tr> |
| | </table> | | </table> |
| - | <div style="background-color:#fffaf0;">
| + | == Function == |
| - | == Publication Abstract from PubMed == | + | [https://www.uniprot.org/uniprot/O54308_STRSZ O54308_STRSZ] |
| - | The protein rTRD is the recombinant form of the target recognition domain of zoocin A, a lytic exoenzyme produced by Streptococcus equi subspecies zooepidemicus 4881. It has no known sequence homologs. However, the catalytic domain of zoocin A is homologous to lysostaphin which is another exoenzyme active against a different spectrum of bacteria, including the pathogen Staphylococcus aureus. An ensemble of models for the solution structure of rTRD has been generated by NMR techniques. The minimum energy model from the ensemble was subjected to three-dimensional homology search engines, but no homologs were found, suggesting rTRD may represent a new protein folding family. There is some similarity in the folding of rTRD to the immunoglobin fold of the antigen binding region of mammalian antibodies which could suggest an ancient evolutionary relation. Proteins 2012. (c) 2012 Wiley Periodicals, Inc.
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| - | Solution structure of the recombinant target recognition domain of zoocin a.,Chen Y, Simmonds RS, Young JK, Timkovich R Proteins. 2012 Nov 27. doi: 10.1002/prot.24224. PMID:23184858<ref>PMID:23184858</ref>
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| - | | + | |
| - | From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
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| - | </div>
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| - | <div class="pdbe-citations 2ls0" style="background-color:#fffaf0;"></div>
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| - | == References ==
| + | |
| - | <references/>
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| | __TOC__ | | __TOC__ |
| | </StructureSection> | | </StructureSection> |
| - | [[Category: Animal pyogenes, type a edwards 1934]] | + | [[Category: Large Structures]] |
| - | [[Category: Chen, Y]] | + | [[Category: Streptococcus equi subsp. zooepidemicus]] |
| - | [[Category: Simmonds, R S]] | + | [[Category: Chen Y]] |
| - | [[Category: Timkovich, R]] | + | [[Category: Simmonds RS]] |
| - | [[Category: Hydrolase]] | + | [[Category: Timkovich R]] |
| - | [[Category: Specificity]]
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