6adq

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'''Unreleased structure'''
 
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The entry 6adq is ON HOLD
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==Respiratory Complex CIII2CIV2SOD2 from Mycobacterium smegmatis==
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<SX load='6adq' size='340' side='right' viewer='molstar' caption='[[6adq]], [[Resolution|resolution]] 3.50&Aring;' scene=''>
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== Structural highlights ==
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<table><tr><td colspan='2'>[[6adq]] is a 20 chain structure with sequence from [https://en.wikipedia.org/wiki/Mycolicibacterium_smegmatis_MC2_51 Mycolicibacterium smegmatis MC2 51]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6ADQ OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6ADQ FirstGlance]. <br>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Electron Microscopy, [[Resolution|Resolution]] 3.5&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=9XX:(2S)-1-(hexadecanoyloxy)propan-2-yl+(10S)-10-methyloctadecanoate'>9XX</scene>, <scene name='pdbligand=9Y0:(2R)-3-{[(R)-(2-aminoethoxy)(hydroxy)phosphoryl]oxy}-2-(hexadecanoyloxy)propyl+(9Z)-octadec-9-enoate'>9Y0</scene>, <scene name='pdbligand=9YF:(2R)-2-(hexadecanoyloxy)-3-{[(S)-hydroxy{[(1R,2R,3R,4R,5R,6S)-2,3,4,5,6-pentahydroxycyclohexyl]oxy}phosphoryl]oxy}propyl+(9S)-9-methyloctadecanoate'>9YF</scene>, <scene name='pdbligand=CDL:CARDIOLIPIN'>CDL</scene>, <scene name='pdbligand=CU:COPPER+(II)+ION'>CU</scene>, <scene name='pdbligand=FES:FE2/S2+(INORGANIC)+CLUSTER'>FES</scene>, <scene name='pdbligand=HEA:HEME-A'>HEA</scene>, <scene name='pdbligand=HEC:HEME+C'>HEC</scene>, <scene name='pdbligand=HEM:PROTOPORPHYRIN+IX+CONTAINING+FE'>HEM</scene>, <scene name='pdbligand=MQ9:MENAQUINONE-9'>MQ9</scene>, <scene name='pdbligand=PLM:PALMITIC+ACID'>PLM</scene></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6adq FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6adq OCA], [https://pdbe.org/6adq PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6adq RCSB], [https://www.ebi.ac.uk/pdbsum/6adq PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6adq ProSAT]</span></td></tr>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/A0R057_MYCS2 A0R057_MYCS2]
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<div style="background-color:#fffaf0;">
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== Publication Abstract from PubMed ==
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We report a 3.5-A resolution cryo-EM structure of a respiratory supercomplex isolated from Mycobacterium smegmatis. It comprises a complex III dimer flanked on either side by individual complex IV subunits. Complex III and IV associate such that electrons can be transferred from quinol in complex III to the oxygen reduction center in complex IV via a bridging cytochrome subunit. We observe a superoxide dismutase-like subunit at the periplasmic face, which may be responsible for detoxification of superoxide formed by complex III. The structure reveals features of an established drug target and provides a foundation for development of treatments for human tuberculosis.
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Authors:
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An electron transfer path connects subunits of a mycobacterial respiratory supercomplex.,Gong H, Li J, Xu A, Tang Y, Ji W, Gao R, Wang S, Yu L, Tian C, Li J, Yen HY, Man Lam S, Shui G, Yang X, Sun Y, Li X, Jia M, Yang C, Jiang B, Lou Z, Robinson CV, Wong LL, Guddat LW, Sun F, Wang Q, Rao Z Science. 2018 Oct 25. pii: science.aat8923. doi: 10.1126/science.aat8923. PMID:30361386<ref>PMID:30361386</ref>
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Description:
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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[[Category: Unreleased Structures]]
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</div>
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<div class="pdbe-citations 6adq" style="background-color:#fffaf0;"></div>
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==See Also==
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*[[Cytochrome c oxidase 3D structures|Cytochrome c oxidase 3D structures]]
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*[[Superoxide dismutase 3D structures|Superoxide dismutase 3D structures]]
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== References ==
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<references/>
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__TOC__
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</SX>
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[[Category: Large Structures]]
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[[Category: Mycolicibacterium smegmatis MC2 51]]
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[[Category: Gao RG]]
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[[Category: Gong HR]]
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[[Category: Ji WX]]
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[[Category: Li J]]
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[[Category: Rao ZH]]
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[[Category: Wang Q]]
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[[Category: Wang SH]]
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[[Category: Xu A]]

Current revision

Respiratory Complex CIII2CIV2SOD2 from Mycobacterium smegmatis

6adq, resolution 3.50Å

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