6e8d
From Proteopedia
(Difference between revisions)
(New page: '''Unreleased structure''' The entry 6e8d is ON HOLD Authors: Guarne, A., Almawi, A.W. Description: Crystal structure of the Bacillus subtilis sliding clamp-MutL complex. [[Category: U...) |
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| - | '''Unreleased structure''' | ||
| - | + | ==Crystal structure of the Bacillus subtilis sliding clamp-MutL complex.== | |
| - | + | <StructureSection load='6e8d' size='340' side='right'caption='[[6e8d]], [[Resolution|resolution]] 2.34Å' scene=''> | |
| - | + | == Structural highlights == | |
| - | + | <table><tr><td colspan='2'>[[6e8d]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Bacillus_subtilis Bacillus subtilis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6E8D OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6E8D FirstGlance]. <br> | |
| - | + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.34Å</td></tr> | |
| - | [[Category: | + | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=GOL:GLYCEROL'>GOL</scene></td></tr> |
| - | [[Category: | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6e8d FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6e8d OCA], [https://pdbe.org/6e8d PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6e8d RCSB], [https://www.ebi.ac.uk/pdbsum/6e8d PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6e8d ProSAT]</span></td></tr> |
| - | [[Category: Almawi | + | </table> |
| + | == Function == | ||
| + | [https://www.uniprot.org/uniprot/DPO3B_BACSU DPO3B_BACSU] DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity. The beta chain is required for initiation of replication once it is clamped onto DNA, it slides freely (bidirectional and ATP-independent) along duplex DNA.[https://www.uniprot.org/uniprot/MUTL_BACSU MUTL_BACSU] This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a "molecular matchmaker", a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex (By similarity). Overexpression of mutSL partially suppresses the high spontaneous mutation frequency of a ytkD/mutM/yfhQ triple disruption which lacks the system required to prevent damage by oxidized guanine (8-oxo-dGTP). This suggests that MutSL also functions to repair mismatches due to oxidative stress in both growing and stationary phase cells.<ref>PMID:19011023</ref> | ||
| + | == References == | ||
| + | <references/> | ||
| + | __TOC__ | ||
| + | </StructureSection> | ||
| + | [[Category: Bacillus subtilis]] | ||
| + | [[Category: Large Structures]] | ||
| + | [[Category: Almawi AW]] | ||
| + | [[Category: Guarne A]] | ||
Current revision
Crystal structure of the Bacillus subtilis sliding clamp-MutL complex.
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