6e93
From Proteopedia
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| - | '''Unreleased structure''' | ||
| - | + | ==Crystal Structure of ZBTB38 C-terminal Zinc Fingers 6-9 in complex with methylated DNA== | |
| - | + | <StructureSection load='6e93' size='340' side='right'caption='[[6e93]], [[Resolution|resolution]] 1.75Å' scene=''> | |
| - | + | == Structural highlights == | |
| - | + | <table><tr><td colspan='2'>[[6e93]] is a 3 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6E93 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6E93 FirstGlance]. <br> | |
| - | + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.747Å</td></tr> | |
| - | [[Category: | + | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=5CM:5-METHYL-2-DEOXY-CYTIDINE-5-MONOPHOSPHATE'>5CM</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr> |
| + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6e93 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6e93 OCA], [https://pdbe.org/6e93 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6e93 RCSB], [https://www.ebi.ac.uk/pdbsum/6e93 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6e93 ProSAT]</span></td></tr> | ||
| + | </table> | ||
| + | == Function == | ||
| + | [https://www.uniprot.org/uniprot/ZBT38_HUMAN ZBT38_HUMAN] Transcriptional regulator with bimodal DNA-binding specificity. Binds with a higher affinity to methylated CpG dinucleotides in the consensus sequence 5'-CGCG-3' but can also bind to E-box elements (5'-CACGTG-3'). Can also bind specifically to a single methyl-CpG pair. Represses transcription in a methyl-CpG-dependent manner (PubMed:16354688). Plays an important role in regulating DNA replication and common fragile sites (CFS) stability in a RBBP6- and MCM10-dependent manner; represses expression of MCM10 which plays an important role in DNA-replication (PubMed:24726359). Acts as a transcriptional activator. May be involved in the differentiation and/or survival of late postmitotic neurons (By similarity).[UniProtKB:Q5EXX3]<ref>PMID:16354688</ref> <ref>PMID:24726359</ref> | ||
| + | == References == | ||
| + | <references/> | ||
| + | __TOC__ | ||
| + | </StructureSection> | ||
| + | [[Category: Homo sapiens]] | ||
| + | [[Category: Large Structures]] | ||
| + | [[Category: Buck-Koehntop BA]] | ||
| + | [[Category: Hudson NO]] | ||
| + | [[Category: Whitby FG]] | ||
Current revision
Crystal Structure of ZBTB38 C-terminal Zinc Fingers 6-9 in complex with methylated DNA
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