5yvf

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==Crystal structure of BFA1==
==Crystal structure of BFA1==
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<StructureSection load='5yvf' size='340' side='right' caption='[[5yvf]], [[Resolution|resolution]] 2.80&Aring;' scene=''>
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<StructureSection load='5yvf' size='340' side='right'caption='[[5yvf]], [[Resolution|resolution]] 2.80&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[5yvf]] is a 4 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5YVF OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5YVF FirstGlance]. <br>
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<table><tr><td colspan='2'>[[5yvf]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Arabidopsis_thaliana Arabidopsis thaliana]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5YVF OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5YVF FirstGlance]. <br>
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</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5yvf FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5yvf OCA], [http://pdbe.org/5yvf PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5yvf RCSB], [http://www.ebi.ac.uk/pdbsum/5yvf PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5yvf ProSAT]</span></td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.804&#8491;</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5yvf FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5yvf OCA], [https://pdbe.org/5yvf PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5yvf RCSB], [https://www.ebi.ac.uk/pdbsum/5yvf PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5yvf ProSAT]</span></td></tr>
</table>
</table>
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<div style="background-color:#fffaf0;">
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== Function ==
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== Publication Abstract from PubMed ==
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[https://www.uniprot.org/uniprot/F4J1U2_ARATH F4J1U2_ARATH]
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F-type ATP synthases produce nearly all of the ATP found in cells. The catalytic module, F1, commonly comprises an alpha3beta3 hexamer surrounding a gamma/epsilon stalk. However, it is unclear how these subunits assemble to form a catalytic motor. In this work, we identified and characterized a chloroplast protein that interacts with the CF1beta, gamma, and epsilon subunits of the chloroplast ATP synthase and is required for assembly of its F1 module. We have named this protein BFA1 (BIOGENESIS FACTOR REQUIRED FOR ATP SYNTHASE 1) and determined its crystal structure at 2.8A resolution. BFA1 is comprised primarily of two interacting beta-barrels that are oriented nearly perpendicularly to each other. The contact region between BFA1 and the CF1beta and gamma subunits was further mapped by yeast two-hybrid assays. An in silico molecular docking analysis was performed and revealed close fitting contact sites without steric conflicts between BFA1 and CF1beta/gamma. We propose that BFA1 acts mainly as a scaffold protein promoting the association of a CF1alpha/beta heterodimer with CF1gamma. The subsequent assembly of other CF1alpha/beta heterodimers may shift the position of the CF1gamma subunit to complete assembly of the CF1 module. This CF1 assembly process is likely to be valid for other F-type ATP synthases, as their structures are highly conserved.
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Nucleus-Encoded Protein BFA1 Promotes Efficient Assembly of the Chloroplast ATP Synthase Coupling Factor 1.,Zhang L, Pu H, Duan Z, Li Y, Liu B, Zhang Q, Li W, Rochaix JD, Liu L, Peng L Plant Cell. 2018 Jul 16. pii: tpc.18.00075. doi: 10.1105/tpc.18.00075. PMID:30012777<ref>PMID:30012777</ref>
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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</div>
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<div class="pdbe-citations 5yvf" style="background-color:#fffaf0;"></div>
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== References ==
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<references/>
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__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Duan, Z K]]
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[[Category: Arabidopsis thaliana]]
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[[Category: Liu, L]]
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[[Category: Large Structures]]
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[[Category: Peng, L W]]
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[[Category: Duan ZK]]
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[[Category: Pu, H]]
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[[Category: Liu L]]
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[[Category: Zhang, L]]
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[[Category: Peng LW]]
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[[Category: Assembly]]
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[[Category: Pu H]]
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[[Category: Atp synthase]]
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[[Category: Zhang L]]
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[[Category: Fba1]]
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[[Category: Plant protein]]
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Current revision

Crystal structure of BFA1

PDB ID 5yvf

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