6a90

From Proteopedia

(Difference between revisions)

Current revision

Complex of voltage-gated sodium channel NavPaS from American cockroach Periplaneta americana and Dc1a

6a90, resolution 2.80Å

Structural highlights

6a90 is a 2 chain structure with sequence from Diguetia canities and Periplaneta americana. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance.
Method:	Electron Microscopy, Resolution 2.8Å
Ligands:
Experimental data:	Check to display Experimental Data
Resources:	FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT

Function

SCNA1_PERAM Mediates the voltage-dependent sodium ion permeability of excitable membranes.[RuleBase:RU361132]^[1]

Publication Abstract from PubMed

Animal toxins that modulate the activity of Nav channels are broadly divided into two categories-pore blockers and gating modifiers. The pore blockers tetrodotoxin (TTX) and saxitoxin (STX) are responsible for pufferfish and shellfish poisoning in humans, respectively. Here we present structures of the insect Nav channel NavPaS bound to a gating modifier toxin Dc1a at 2.8 A and in the presence of TTX or STX at 2.6 A and 3.2 A resolution, respectively. Dc1a inserts into the cleft between VSDII and the pore of NavPaS, making key contacts with both domains. The structures with bound TTX or STX reveal the molecular details for the specific blockade of Na(+) access to the selectivity filter from the extracellular side by these guanidinium toxins. The structures shed light on structure-based development of Nav channel drugs.

Structural basis for the modulation of voltage-gated sodium channels by animal toxins.,Shen H, Li Z, Jiang Y, Pan X, Wu J, Cristofori-Armstrong B, Smith JJ, Chin YKY, Lei J, Zhou Q, King GF, Yan N Science. 2018 Jul 26. pii: science.aau2596. doi: 10.1126/science.aau2596. PMID:30049784^[2]

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.

References

↑ Shen H, Zhou Q, Pan X, Li Z, Wu J, Yan N. Structure of a eukaryotic voltage-gated sodium channel at near-atomic resolution. Science. 2017 Mar 3;355(6328). pii: eaal4326. doi: 10.1126/science.aal4326. Epub , 2017 Feb 9. PMID:28183995 doi:http://dx.doi.org/10.1126/science.aal4326
↑ Shen H, Li Z, Jiang Y, Pan X, Wu J, Cristofori-Armstrong B, Smith JJ, Chin YKY, Lei J, Zhou Q, King GF, Yan N. Structural basis for the modulation of voltage-gated sodium channels by animal toxins. Science. 2018 Jul 26. pii: science.aau2596. doi: 10.1126/science.aau2596. PMID:30049784 doi:http://dx.doi.org/10.1126/science.aau2596

1 Structural highlights
2 Function
3 Publication Abstract from PubMed
4 See Also
5 References

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/6a90"

@@ Line 1: / Line 1: @@
 ==Complex of voltage-gated sodium channel NavPaS from American cockroach Periplaneta americana and Dc1a==
-<StructureSection load='6a90' size='340' side='right' caption='[[6a90]], [[Resolution|resolution]] 2.80&Aring;' scene=''>
+<SX load='6a90' size='340' side='right' viewer='molstar' caption='[[6a90]], [[Resolution|resolution]] 2.80&Aring;' scene=''>
 == Structural highlights ==
-<table><tr><td colspan='2'>[[6a90]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6A90 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6A90 FirstGlance]. <br>
+<table><tr><td colspan='2'>[[6a90]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Diguetia_canities Diguetia canities] and [https://en.wikipedia.org/wiki/Periplaneta_americana Periplaneta americana]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6A90 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6A90 FirstGlance]. <br>
-</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=NA:SODIUM+ION'>NA</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene></td></tr>
+</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Electron Microscopy, [[Resolution|Resolution]] 2.8&#8491;</td></tr>
-<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6a90 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6a90 OCA], [http://pdbe.org/6a90 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6a90 RCSB], [http://www.ebi.ac.uk/pdbsum/6a90 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6a90 ProSAT]</span></td></tr>
+<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=NA:SODIUM+ION'>NA</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene></td></tr>
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6a90 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6a90 OCA], [https://pdbe.org/6a90 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6a90 RCSB], [https://www.ebi.ac.uk/pdbsum/6a90 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6a90 ProSAT]</span></td></tr>
 </table>
 == Function ==
-[[http://www.uniprot.org/uniprot/SCNA1_PERAM SCNA1_PERAM]] Mediates the voltage-dependent sodium ion permeability of excitable membranes.[RuleBase:RU361132]<ref>PMID:28183995</ref>
+[https://www.uniprot.org/uniprot/SCNA1_PERAM SCNA1_PERAM] Mediates the voltage-dependent sodium ion permeability of excitable membranes.[RuleBase:RU361132]<ref>PMID:28183995</ref>
 <div style="background-color:#fffaf0;">
 == Publication Abstract from PubMed ==
@@ Line 18: / Line 19: @@
 </div>
 <div class="pdbe-citations 6a90" style="background-color:#fffaf0;"></div>
+==See Also==
+*[[Ion channels 3D structures|Ion channels 3D structures]]
 == References ==
 <references/>
 __TOC__
-</StructureSection>
+</SX>
-[[Category: Chin, Y K.Y]]
+[[Category: Diguetia canities]]
-[[Category: Cristofori-Armstrong, B]]
+[[Category: Large Structures]]
-[[Category: Jiang, Y]]
+[[Category: Periplaneta americana]]
-[[Category: King, G F]]
+[[Category: Chin YKY]]
-[[Category: Lei, J L]]
+[[Category: Cristofori-Armstrong B]]
-[[Category: Pan, X J]]
+[[Category: Jiang Y]]
-[[Category: Shen, H Z]]
+[[Category: King GF]]
-[[Category: Smith, J J]]
+[[Category: Lei JL]]
-[[Category: Wu, J P]]
+[[Category: Pan XJ]]
-[[Category: Yan, N]]
+[[Category: Shen HZ]]
-[[Category: Zhou, Q]]
+[[Category: Smith JJ]]
-[[Category: Li, Z Q]]
+[[Category: Wu JP]]
-[[Category: Complex]]
+[[Category: Yan N]]
-[[Category: Membrane protein]]
+[[Category: Zhou Q]]
-[[Category: Membrane protein-toxin complex]]
+[[Category: Li ZQ]]
-[[Category: Sodium channel]]
-[[Category: Toxin]]

6a90

From Proteopedia

Current revision

Complex of voltage-gated sodium channel NavPaS from American cockroach Periplaneta americana and Dc1a

Structural highlights

Function

Publication Abstract from PubMed

See Also

References

Contents

Proteopedia Page Contributors and Editors (what is this?)

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