2os1

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[[Image:2os1.jpg|left|200px]]
 
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{{Structure
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==Structures of actinonin bound peptide deformylases from E. faecalis and S. pyogenes==
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|PDB= 2os1 |SIZE=350|CAPTION= <scene name='initialview01'>2os1</scene>, resolution 1.50&Aring;
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<StructureSection load='2os1' size='340' side='right'caption='[[2os1]], [[Resolution|resolution]] 1.50&Aring;' scene=''>
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|SITE= <scene name='pdbsite=AC1:Ni+Binding+Site+For+Residue+A+300'>AC1</scene>, <scene name='pdbsite=AC2:So4+Binding+Site+For+Residue+A+501'>AC2</scene>, <scene name='pdbsite=AC3:So4+Binding+Site+For+Residue+A+502'>AC3</scene>, <scene name='pdbsite=AC4:So4+Binding+Site+For+Residue+A+503'>AC4</scene> and <scene name='pdbsite=AC5:Bb2+Binding+Site+For+Residue+A+400'>AC5</scene>
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== Structural highlights ==
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|LIGAND= <scene name='pdbligand=BB2:ACTINONIN'>BB2</scene>, <scene name='pdbligand=NI:NICKEL+(II)+ION'>NI</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene>
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<table><tr><td colspan='2'>[[2os1]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Enterococcus_faecalis Enterococcus faecalis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2OS1 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2OS1 FirstGlance]. <br>
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|ACTIVITY= <span class='plainlinks'>[http://en.wikipedia.org/wiki/Peptide_deformylase Peptide deformylase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.5.1.88 3.5.1.88] </span>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.5&#8491;</td></tr>
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|GENE= def ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=1351 Enterococcus faecalis])
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=BB2:ACTINONIN'>BB2</scene>, <scene name='pdbligand=NI:NICKEL+(II)+ION'>NI</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
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|DOMAIN=
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2os1 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2os1 OCA], [https://pdbe.org/2os1 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2os1 RCSB], [https://www.ebi.ac.uk/pdbsum/2os1 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2os1 ProSAT]</span></td></tr>
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|RELATEDENTRY=[[2os0|2OS0]], [[2os3|2OS3]]
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</table>
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|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2os1 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2os1 OCA], [http://www.ebi.ac.uk/pdbsum/2os1 PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=2os1 RCSB]</span>
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== Function ==
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}}
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[https://www.uniprot.org/uniprot/DEF_ENTFA DEF_ENTFA] Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions (By similarity).
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== Evolutionary Conservation ==
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'''Structures of actinonin bound peptide deformylases from E. faecalis and S. pyogenes'''
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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==About this Structure==
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/os/2os1_consurf.spt"</scriptWhenChecked>
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2OS1 is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Enterococcus_faecalis Enterococcus faecalis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2OS1 OCA].
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2os1 ConSurf].
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<div style="clear:both"></div>
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__TOC__
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</StructureSection>
[[Category: Enterococcus faecalis]]
[[Category: Enterococcus faecalis]]
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[[Category: Peptide deformylase]]
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[[Category: Large Structures]]
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[[Category: Single protein]]
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[[Category: Choi K]]
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[[Category: Choi, K.]]
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[[Category: Kim EE]]
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[[Category: Kim, E E.]]
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[[Category: Kim K-H]]
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[[Category: Kim, K H.]]
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[[Category: Lee HK]]
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[[Category: Lee, H K.]]
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[[Category: Moon JH]]
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[[Category: Moon, J H.]]
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[[Category: Park HS]]
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[[Category: Park, H S.]]
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[[Category: hydrolase]]
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[[Category: pdf]]
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[[Category: peptide deformylase]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Mar 31 04:22:19 2008''
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Current revision

Structures of actinonin bound peptide deformylases from E. faecalis and S. pyogenes

PDB ID 2os1

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OCA

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