2os5

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[[Image:2os5.jpg|left|200px]]
 
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{{Structure
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==Macrophage migration inhibitory factor from Ancylostoma ceylanicum==
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|PDB= 2os5 |SIZE=350|CAPTION= <scene name='initialview01'>2os5</scene>, resolution 1.60&Aring;
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<StructureSection load='2os5' size='340' side='right'caption='[[2os5]], [[Resolution|resolution]] 1.60&Aring;' scene=''>
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|SITE= <scene name='pdbsite=AC1:So4+Binding+Site+For+Residue+D+201'>AC1</scene>, <scene name='pdbsite=AC2:So4+Binding+Site+For+Residue+A+202'>AC2</scene>, <scene name='pdbsite=AC3:So4+Binding+Site+For+Residue+A+203'>AC3</scene> and <scene name='pdbsite=AC4:So4+Binding+Site+For+Residue+B+204'>AC4</scene>
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== Structural highlights ==
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|LIGAND= <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene>
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<table><tr><td colspan='2'>[[2os5]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Ancylostoma_ceylanicum Ancylostoma ceylanicum]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2OS5 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2OS5 FirstGlance]. <br>
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|ACTIVITY=
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.6&#8491;</td></tr>
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|GENE=
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
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|DOMAIN=
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2os5 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2os5 OCA], [https://pdbe.org/2os5 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2os5 RCSB], [https://www.ebi.ac.uk/pdbsum/2os5 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2os5 ProSAT]</span></td></tr>
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|RELATEDENTRY=
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</table>
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|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2os5 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2os5 OCA], [http://www.ebi.ac.uk/pdbsum/2os5 PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=2os5 RCSB]</span>
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== Function ==
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}}
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[https://www.uniprot.org/uniprot/A4GRE3_9BILA A4GRE3_9BILA]
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/os/2os5_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2os5 ConSurf].
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<div style="clear:both"></div>
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'''Macrophage migration inhibitory factor from Ancylostoma ceylanicum'''
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==See Also==
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*[[Macrophage inhibitory factor 3D structures|Macrophage inhibitory factor 3D structures]]
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__TOC__
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==Overview==
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</StructureSection>
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Hookworms, parasitic nematodes that infect nearly one billion people worldwide, are a major cause of anemia and malnutrition. We hypothesize that hookworms actively manipulate the host immune response through the production of specific molecules designed to facilitate infection by larval stages and adult worm survival within the intestine. A full-length cDNA encoding a secreted orthologue of the human cytokine, Macrophage Migration Inhibitory Factor (MIF) has been cloned from the hookworm Ancylostoma ceylanicum. Elucidation of the three-dimensional crystal structure of recombinant AceMIF (rAceMIF) revealed an overall structural homology with significant differences in the tautomerase sites of the human and hookworm proteins. The relative bioactivities of human and hookworm MIF proteins were compared using in vitro assays of tautomerase activity, macrophage migration, and binding to MIF receptor CD74. The activity of rAceMIF was not inhibited by the ligand ISO-1, which was previously determined to be an inhibitor of the catalytic site of human MIF. These data define unique immunological, structural, and functional characteristics of AceMIF, thereby establishing the potential for selectively inhibiting the hookworm cytokine as a means of reducing parasite survival and disease pathogenesis.
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==About this Structure==
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2OS5 is a [[Protein complex]] structure of sequences from [http://en.wikipedia.org/wiki/Ancylostoma_ceylanicum Ancylostoma ceylanicum]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2OS5 OCA].
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==Reference==
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Structural and functional characterization of a secreted hookworm Macrophage Migration Inhibitory Factor (MIF) that interacts with the human MIF receptor CD74., Cho Y, Jones BF, Vermeire JJ, Leng L, DiFedele L, Harrison LM, Xiong H, Kwong YK, Chen Y, Bucala R, Lolis E, Cappello M, J Biol Chem. 2007 Aug 10;282(32):23447-56. Epub 2007 Jun 13. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/17567581 17567581]
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[[Category: Ancylostoma ceylanicum]]
[[Category: Ancylostoma ceylanicum]]
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[[Category: Protein complex]]
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[[Category: Large Structures]]
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[[Category: Cho, Y.]]
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[[Category: Cho Y]]
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[[Category: Lolis, E.]]
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[[Category: Lolis E]]
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[[Category: cytokine]]
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[[Category: hookworm]]
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[[Category: macrophage migration inhibitory factor]]
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[[Category: nematode]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Mar 31 04:22:20 2008''
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Current revision

Macrophage migration inhibitory factor from Ancylostoma ceylanicum

PDB ID 2os5

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