2osz

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[[Image:2osz.gif|left|200px]]
 
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{{Structure
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==Structure of Nup58/45 suggests flexible nuclear pore diameter by intermolecular sliding==
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|PDB= 2osz |SIZE=350|CAPTION= <scene name='initialview01'>2osz</scene>, resolution 2.85&Aring;
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<StructureSection load='2osz' size='340' side='right'caption='[[2osz]], [[Resolution|resolution]] 2.85&Aring;' scene=''>
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|SITE=
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== Structural highlights ==
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|LIGAND=
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<table><tr><td colspan='2'>[[2osz]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Rattus_norvegicus Rattus norvegicus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2OSZ OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2OSZ FirstGlance]. <br>
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|ACTIVITY=
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.85&#8491;</td></tr>
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|GENE= Nupl1 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10116 Rattus norvegicus])
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2osz FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2osz OCA], [https://pdbe.org/2osz PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2osz RCSB], [https://www.ebi.ac.uk/pdbsum/2osz PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2osz ProSAT]</span></td></tr>
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|DOMAIN=
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</table>
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|RELATEDENTRY=
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== Function ==
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|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2osz FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2osz OCA], [http://www.ebi.ac.uk/pdbsum/2osz PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=2osz RCSB]</span>
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[https://www.uniprot.org/uniprot/NUP58_RAT NUP58_RAT] Component of the nuclear pore complex, a complex required for the trafficking across the nuclear membrane.<ref>PMID:8707840</ref>
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}}
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/os/2osz_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2osz ConSurf].
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<div style="clear:both"></div>
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'''Structure of Nup58/45 suggests flexible nuclear pore diameter by intermolecular sliding'''
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==See Also==
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*[[Nucleoporin 3D structures|Nucleoporin 3D structures]]
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== References ==
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==Overview==
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<references/>
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The nucleoporins Nup58 and Nup45 are part of the central transport channel of the nuclear pore complex, which is thought to have a flexible diameter. In the crystal structure of an alpha-helical region of mammalian Nup58/45, we identified distinct tetramers, each consisting of two antiparallel hairpin dimers. The intradimeric interface is hydrophobic, whereas dimer-dimer association occurs through large hydrophilic residues. These residues are laterally displaced in various tetramer conformations, which suggests an intermolecular sliding by 11 angstroms. We propose that circumferential sliding plays a role in adjusting the diameter of the central transport channel.
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__TOC__
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</StructureSection>
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==About this Structure==
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[[Category: Large Structures]]
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2OSZ is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Rattus_norvegicus Rattus norvegicus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2OSZ OCA].
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==Reference==
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Structure of Nup58/45 suggests flexible nuclear pore diameter by intermolecular sliding., Melcak I, Hoelz A, Blobel G, Science. 2007 Mar 23;315(5819):1729-32. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/17379812 17379812]
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[[Category: Rattus norvegicus]]
[[Category: Rattus norvegicus]]
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[[Category: Single protein]]
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[[Category: Blobel G]]
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[[Category: Blobel, G.]]
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[[Category: Hoelz A]]
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[[Category: Hoelz, A.]]
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[[Category: Melcak I]]
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[[Category: Melcak, I.]]
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[[Category: npc]]
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[[Category: nucleoporin]]
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[[Category: structure]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Mar 31 04:22:43 2008''
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Current revision

Structure of Nup58/45 suggests flexible nuclear pore diameter by intermolecular sliding

PDB ID 2osz

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