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| | ==Structure of Plasmodium Yoelii Merozoite Surface Protein 1 - C-terminal Domain, E28K mutant== | | ==Structure of Plasmodium Yoelii Merozoite Surface Protein 1 - C-terminal Domain, E28K mutant== |
| - | <StructureSection load='2mgr' size='340' side='right' caption='[[2mgr]], [[NMR_Ensembles_of_Models | 20 NMR models]]' scene=''> | + | <StructureSection load='2mgr' size='340' side='right'caption='[[2mgr]]' scene=''> |
| | == Structural highlights == | | == Structural highlights == |
| - | <table><tr><td colspan='2'>[[2mgr]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Playo Playo]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2MGR OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2MGR FirstGlance]. <br> | + | <table><tr><td colspan='2'>[[2mgr]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Plasmodium_yoelii_yoelii Plasmodium yoelii yoelii]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2MGR OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2MGR FirstGlance]. <br> |
| - | </td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[2mgp|2mgp]]</td></tr> | + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr> |
| - | <tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">MSP-1 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=73239 PLAYO])</td></tr>
| + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2mgr FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2mgr OCA], [https://pdbe.org/2mgr PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2mgr RCSB], [https://www.ebi.ac.uk/pdbsum/2mgr PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2mgr ProSAT]</span></td></tr> |
| - | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2mgr FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2mgr OCA], [http://pdbe.org/2mgr PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2mgr RCSB], [http://www.ebi.ac.uk/pdbsum/2mgr PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=2mgr ProSAT]</span></td></tr> | + | |
| | </table> | | </table> |
| | + | == Function == |
| | + | [https://www.uniprot.org/uniprot/MSP1_PLAYO MSP1_PLAYO] |
| | <div style="background-color:#fffaf0;"> | | <div style="background-color:#fffaf0;"> |
| | == Publication Abstract from PubMed == | | == Publication Abstract from PubMed == |
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| | __TOC__ | | __TOC__ |
| | </StructureSection> | | </StructureSection> |
| - | [[Category: Playo]] | + | [[Category: Large Structures]] |
| - | [[Category: Birdsall, B]] | + | [[Category: Plasmodium yoelii yoelii]] |
| - | [[Category: Curd, R D]] | + | [[Category: Birdsall B]] |
| - | [[Category: Holder, A A]] | + | [[Category: Curd RD]] |
| - | [[Category: Kadekoppala, M]] | + | [[Category: Holder AA]] |
| - | [[Category: Kelly, G]] | + | [[Category: Kadekoppala M]] |
| - | [[Category: Ogun, S]] | + | [[Category: Kelly G]] |
| - | [[Category: Membrane protein]]
| + | [[Category: Ogun S]] |
| Structural highlights
Function
MSP1_PLAYO
Publication Abstract from PubMed
Merozoite surface protein 1 (MSP1) has been identified as a target antigen for protective immune responses against asexual blood stage malaria, but effective vaccines based on MSP1 have not been developed so far. We have modified the sequence of Plasmodium yoelii MSP119 (the C-terminal region of the molecule) and examined the ability of the variant proteins to bind protective monoclonal antibodies and to induce protection by immunization. In parallel, we examined the structure of the protein and the consequences of the amino acid changes. Naturally occurring sequence polymorphisms reduced the binding of individual protective antibodies, indicating that they contribute to immune evasion, but immunization with these variant proteins still provided protective immunity. One variant that resulted in the localized distortion of a loop close to the N-terminus of MSP119 almost completely ablated protection by immunization, indicating the importance of this region of MSP119 as a target for protective immunity and in vaccine development.
The structure of Plasmodium yoelii merozoite surface protein 119, antibody specificity and implications for malaria vaccine design.,Curd RD, Birdsall B, Kadekoppala M, Ogun SA, Kelly G, Holder AA Open Biol. 2014 Jan 8;4(1):130091. doi: 10.1098/rsob.130091. PMID:24403012[1]
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.
References
- ↑ Curd RD, Birdsall B, Kadekoppala M, Ogun SA, Kelly G, Holder AA. The structure of Plasmodium yoelii merozoite surface protein 119, antibody specificity and implications for malaria vaccine design. Open Biol. 2014 Jan 8;4(1):130091. doi: 10.1098/rsob.130091. PMID:24403012 doi:http://dx.doi.org/10.1098/rsob.130091
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