|
|
| (2 intermediate revisions not shown.) |
| Line 1: |
Line 1: |
| | | | |
| | ==NMR structure of Ca2+ bound CaBP4 N-domain== | | ==NMR structure of Ca2+ bound CaBP4 N-domain== |
| - | <StructureSection load='2m29' size='340' side='right' caption='[[2m29]], [[NMR_Ensembles_of_Models | 15 NMR models]]' scene=''> | + | <StructureSection load='2m29' size='340' side='right'caption='[[2m29]]' scene=''> |
| | == Structural highlights == | | == Structural highlights == |
| - | <table><tr><td colspan='2'>[[2m29]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Lk3_transgenic_mice Lk3 transgenic mice]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2M29 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2M29 FirstGlance]. <br> | + | <table><tr><td colspan='2'>[[2m29]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2M29 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2M29 FirstGlance]. <br> |
| - | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene></td></tr> | + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr> |
| - | <tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[2m28|2m28]]</td></tr> | + | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene></td></tr> |
| - | <tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">Cabp4 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10090 LK3 transgenic mice])</td></tr>
| + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2m29 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2m29 OCA], [https://pdbe.org/2m29 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2m29 RCSB], [https://www.ebi.ac.uk/pdbsum/2m29 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2m29 ProSAT]</span></td></tr> |
| - | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2m29 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2m29 OCA], [http://pdbe.org/2m29 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2m29 RCSB], [http://www.ebi.ac.uk/pdbsum/2m29 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=2m29 ProSAT]</span></td></tr> | + | |
| | </table> | | </table> |
| | == Function == | | == Function == |
| - | [[http://www.uniprot.org/uniprot/CABP4_MOUSE CABP4_MOUSE]] Involved in normal synaptic function through regulation of Ca(2+) influx and neurotransmitter release in photoreceptor synaptic terminals and in auditory transmission. Modulator of CACNA1D and CACNA1F, suppressing the calcium-dependent inactivation and shifting the activation range to more hyperpolarized voltages.<ref>PMID:15452577</ref> <ref>PMID:16249514</ref> <ref>PMID:17050707</ref> <ref>PMID:17947313</ref> | + | [https://www.uniprot.org/uniprot/CABP4_MOUSE CABP4_MOUSE] Involved in normal synaptic function through regulation of Ca(2+) influx and neurotransmitter release in photoreceptor synaptic terminals and in auditory transmission. Modulator of CACNA1D and CACNA1F, suppressing the calcium-dependent inactivation and shifting the activation range to more hyperpolarized voltages.<ref>PMID:15452577</ref> <ref>PMID:16249514</ref> <ref>PMID:17050707</ref> <ref>PMID:17947313</ref> |
| | == References == | | == References == |
| | <references/> | | <references/> |
| | __TOC__ | | __TOC__ |
| | </StructureSection> | | </StructureSection> |
| - | [[Category: Lk3 transgenic mice]] | + | [[Category: Large Structures]] |
| - | [[Category: Ames, J B]] | + | [[Category: Mus musculus]] |
| - | [[Category: Metal binding protein]] | + | [[Category: Ames JB]] |
| Structural highlights
Function
CABP4_MOUSE Involved in normal synaptic function through regulation of Ca(2+) influx and neurotransmitter release in photoreceptor synaptic terminals and in auditory transmission. Modulator of CACNA1D and CACNA1F, suppressing the calcium-dependent inactivation and shifting the activation range to more hyperpolarized voltages.[1] [2] [3] [4]
References
- ↑ Haeseleer F, Imanishi Y, Maeda T, Possin DE, Maeda A, Lee A, Rieke F, Palczewski K. Essential role of Ca2+-binding protein 4, a Cav1.4 channel regulator, in photoreceptor synaptic function. Nat Neurosci. 2004 Oct;7(10):1079-87. Epub 2004 Sep 26. PMID:15452577 doi:http://dx.doi.org/10.1038/nn1320
- ↑ Maeda T, Lem J, Palczewski K, Haeseleer F. A critical role of CaBP4 in the cone synapse. Invest Ophthalmol Vis Sci. 2005 Nov;46(11):4320-7. PMID:16249514 doi:http://dx.doi.org/10.1167/iovs.05-0478
- ↑ Yang PS, Alseikhan BA, Hiel H, Grant L, Mori MX, Yang W, Fuchs PA, Yue DT. Switching of Ca2+-dependent inactivation of Ca(v)1.3 channels by calcium binding proteins of auditory hair cells. J Neurosci. 2006 Oct 18;26(42):10677-89. PMID:17050707 doi:http://dx.doi.org/10.1523/JNEUROSCI.3236-06.2006
- ↑ Cui G, Meyer AC, Calin-Jageman I, Neef J, Haeseleer F, Moser T, Lee A. Ca2+-binding proteins tune Ca2+-feedback to Cav1.3 channels in mouse auditory hair cells. J Physiol. 2007 Dec 15;585(Pt 3):791-803. Epub 2007 Oct 18. PMID:17947313 doi:http://dx.doi.org/10.1113/jphysiol.2007.142307
|
