2m1g

<StructureSection load='2m1g' size='340' side='right' caption='[[2m1g]], [[NMR_Ensembles_of_Models | 10 NMR models]]' scene=''>

<table><tr><td colspan='2'>[[2m1g]] is a 2 chain structure. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2M1G OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2M1G FirstGlance]. <br>

</td></tr><tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=GFL:2-AMINO-9-(2-DEOXY-2-FLUORO-5-O-PHOSPHONO-BETA-D-ARABINOFURANOSYL)-1,9-DIHYDRO-6H-PURIN-6-ONE'>GFL</scene></td></tr>

<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2m1g FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2m1g OCA], [http://pdbe.org/2m1g PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2m1g RCSB], [http://www.ebi.ac.uk/pdbsum/2m1g PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=2m1g ProSAT]</span></td></tr>

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== Publication Abstract from PubMed ==

Human telomeric DNA quadruplexes can adopt different conformations in solution. We have found that arabinose, 2'F-arabinose, and ribose substitutions stabilize the propeller parallel G-quadruplex form over competing conformers, allowing NMR structural determination of this particularly significant nucleic acid structure. 2'F-arabinose substitution provides the greatest stabilization as a result of electrostatic (F-CH---O4') and pseudo-hydrogen-bond (F---H8) stabilizing interactions. In contrast, 2'F-rG substitution provokes a dramatic destabilization of the quadruplex structure due to unfavorable electrostatic repulsion between the phosphate and the 2'-F.

Dramatic effect of furanose c2' substitution on structure and stability: directing the folding of the human telomeric quadruplex with a single fluorine atom.,Martin-Pintado N, Yahyaee-Anzahaee M, Deleavey GF, Portella G, Orozco M, Damha MJ, Gonzalez C J Am Chem Soc. 2013 Apr 10;135(14):5344-7. doi: 10.1021/ja401954t. Epub 2013 Mar , 27. PMID:23521511<ref>PMID:23521511</ref>

From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>

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<div class="pdbe-citations 2m1g" style="background-color:#fffaf0;"></div>

== References ==

<references/>

[[Category: Damha, M J]]

[[Category: Deleavey, G F]]

[[Category: Gonzalez, C]]

[[Category: Martin-Pintado, N]]

[[Category: Orozco, M]]

[[Category: Portella, G]]

[[Category: Yahyaee-Anzahaee, M]]

[[Category: Parallel g-quadruplex]]