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| | ==Structure of the m04/gp34 mouse Cytomegalovirus Immunoevasin core domain== | | ==Structure of the m04/gp34 mouse Cytomegalovirus Immunoevasin core domain== |
| - | <StructureSection load='2miz' size='340' side='right' caption='[[2miz]], [[NMR_Ensembles_of_Models | 10 NMR models]]' scene=''> | + | <StructureSection load='2miz' size='340' side='right'caption='[[2miz]]' scene=''> |
| | == Structural highlights == | | == Structural highlights == |
| - | <table><tr><td colspan='2'>[[2miz]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Muhvk Muhvk]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2MIZ OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2MIZ FirstGlance]. <br> | + | <table><tr><td colspan='2'>[[2miz]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Murine_cytomegalovirus_(strain_K181) Murine cytomegalovirus (strain K181)]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2MIZ OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2MIZ FirstGlance]. <br> |
| - | </td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">m04 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=69156 MUHVK])</td></tr> | + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR, 10 models</td></tr> |
| - | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2miz FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2miz OCA], [http://pdbe.org/2miz PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2miz RCSB], [http://www.ebi.ac.uk/pdbsum/2miz PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=2miz ProSAT]</span></td></tr> | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2miz FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2miz OCA], [https://pdbe.org/2miz PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2miz RCSB], [https://www.ebi.ac.uk/pdbsum/2miz PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2miz ProSAT]</span></td></tr> |
| | </table> | | </table> |
| | + | == Function == |
| | + | [https://www.uniprot.org/uniprot/A2Q6L0_MUHVK A2Q6L0_MUHVK] |
| | <div style="background-color:#fffaf0;"> | | <div style="background-color:#fffaf0;"> |
| | == Publication Abstract from PubMed == | | == Publication Abstract from PubMed == |
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| | __TOC__ | | __TOC__ |
| | </StructureSection> | | </StructureSection> |
| - | [[Category: Muhvk]] | + | [[Category: Large Structures]] |
| - | [[Category: Bax, A]] | + | [[Category: Bax A]] |
| - | [[Category: Margulies, D H]] | + | [[Category: Margulies DH]] |
| - | [[Category: Natarajan, K]] | + | [[Category: Natarajan K]] |
| - | [[Category: Sgourakis, N G]] | + | [[Category: Sgourakis NG]] |
| - | [[Category: Ilv labelling]]
| + | |
| - | [[Category: Immunoglobulin-like fold]]
| + | |
| - | [[Category: Mhc class-i regulation]]
| + | |
| - | [[Category: Missing-self]]
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| - | [[Category: Natural killer decoy]]
| + | |
| - | [[Category: Residual dipolar coupling]]
| + | |
| - | [[Category: Rosetta modelling]]
| + | |
| - | [[Category: Viral protein]]
| + | |
| Structural highlights
Function
A2Q6L0_MUHVK
Publication Abstract from PubMed
Immunoevasins are key proteins used by viruses to subvert host immune responses. Determining their high-resolution structures is key to understanding virus-host interactions toward the design of vaccines and other antiviral therapies. Mouse cytomegalovirus encodes a unique set of immunoevasins, the m02-m06 family, that modulates major histocompatibility complex class I (MHC-I) antigen presentation to CD8+ T cells and natural killer cells. Notwithstanding the large number of genetic and functional studies, the structural biology of immunoevasins remains incompletely understood, largely because of crystallization bottlenecks. Here we implement a technology using sparse nuclear magnetic resonance data and integrative Rosetta modeling to determine the structure of the m04/gp34 immunoevasin extracellular domain. The structure reveals a beta fold that is representative of the m02-m06 family of viral proteins, several of which are known to bind MHC-I molecules and interfere with antigen presentation, suggesting its role as a diversified immune regulation module.
The structure of mouse cytomegalovirus m04 protein obtained from sparse NMR data reveals a conserved fold of the m02-m06 viral immune modulator family.,Sgourakis NG, Natarajan K, Ying J, Vogeli B, Boyd LF, Margulies DH, Bax A Structure. 2014 Sep 2;22(9):1263-73. doi: 10.1016/j.str.2014.05.018. Epub 2014, Aug 7. PMID:25126960[1]
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.
References
- ↑ Sgourakis NG, Natarajan K, Ying J, Vogeli B, Boyd LF, Margulies DH, Bax A. The structure of mouse cytomegalovirus m04 protein obtained from sparse NMR data reveals a conserved fold of the m02-m06 viral immune modulator family. Structure. 2014 Sep 2;22(9):1263-73. doi: 10.1016/j.str.2014.05.018. Epub 2014, Aug 7. PMID:25126960 doi:http://dx.doi.org/10.1016/j.str.2014.05.018
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