2m9a
From Proteopedia
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==Solution NMR Structure of E3 ubiquitin-protein ligase ZFP91 from Homo sapiens, Northeast Structural Genomics Consortium (NESG) Target HR7784A== | ==Solution NMR Structure of E3 ubiquitin-protein ligase ZFP91 from Homo sapiens, Northeast Structural Genomics Consortium (NESG) Target HR7784A== | ||
| - | <StructureSection load='2m9a' size='340' side='right' caption='[[2m9a | + | <StructureSection load='2m9a' size='340' side='right'caption='[[2m9a]]' scene=''> |
== Structural highlights == | == Structural highlights == | ||
| - | <table><tr><td colspan='2'>[[2m9a]] is a 1 chain structure with sequence from [ | + | <table><tr><td colspan='2'>[[2m9a]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2M9A OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2M9A FirstGlance]. <br> |
| - | </td></tr><tr id=' | + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr> |
| - | <tr id=' | + | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr> |
| - | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[ | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2m9a FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2m9a OCA], [https://pdbe.org/2m9a PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2m9a RCSB], [https://www.ebi.ac.uk/pdbsum/2m9a PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2m9a ProSAT]</span></td></tr> |
</table> | </table> | ||
== Function == | == Function == | ||
| - | [ | + | [https://www.uniprot.org/uniprot/ZFP91_HUMAN ZFP91_HUMAN] Atypical E3 ubiquitin-protein ligase that mediates 'Lys-63'-linked ubiquitination of MAP3K14/NIK, leading to stabilize and activate MAP3K14/NIK. It thereby acts as an activator of the non-canonical NF-kappa-B2/NFKB2 pathway. May also play an important role in cell proliferation and/or anti-apoptosis.<ref>PMID:12738986</ref> <ref>PMID:20682767</ref> |
==See Also== | ==See Also== | ||
| - | *[[Ubiquitin protein ligase|Ubiquitin protein ligase]] | + | *[[Ubiquitin protein ligase 3D structures|Ubiquitin protein ligase 3D structures]] |
== References == | == References == | ||
<references/> | <references/> | ||
__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
| - | [[Category: | + | [[Category: Homo sapiens]] |
| - | [[Category: Acton | + | [[Category: Large Structures]] |
| - | [[Category: Everett | + | [[Category: Acton TB]] |
| - | [[Category: Janjua | + | [[Category: Everett JK]] |
| - | [[Category: Kohan | + | [[Category: Janjua H]] |
| - | [[Category: Montelione | + | [[Category: Kohan E]] |
| - | + | [[Category: Montelione GT]] | |
| - | [[Category: Pederson | + | [[Category: Pederson K]] |
| - | [[Category: Prestegard | + | [[Category: Prestegard JH]] |
| - | [[Category: Shastry | + | [[Category: Shastry R]] |
| - | [[Category: Xiao | + | [[Category: Xiao R]] |
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Current revision
Solution NMR Structure of E3 ubiquitin-protein ligase ZFP91 from Homo sapiens, Northeast Structural Genomics Consortium (NESG) Target HR7784A
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Categories: Homo sapiens | Large Structures | Acton TB | Everett JK | Janjua H | Kohan E | Montelione GT | Pederson K | Prestegard JH | Shastry R | Xiao R
