NADPH dehydrogenase
From Proteopedia
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== Function == | == Function == | ||
| - | '''NADPH dehydrogenase''' or '''old yellow enzyme''' (OYE) catalyzes the conversion of NADPH, H+ and acceptor to NADP+ and reduced acceptor<ref>PMID:12803488</ref>. See [[NAD(P)H]]. The acceptor is a quinone. OYE is a flavoenzyme with two cofactors: FAD and FMN. | + | '''NADPH dehydrogenase''' or '''old yellow enzyme''' or '''NADH:flavin oxidoreductase/NADH oxidase''' or '''prostaglandin F2A synthase''' or '''chromate reductase''' (OYE) catalyzes the conversion of NADPH, H+ and acceptor to NADP+ and reduced acceptor<ref>PMID:12803488</ref>. See [[NAD(P)H]]. The acceptor is a quinone. OYE is a flavoenzyme with two cofactors: FAD and FMN. |
| + | *'''NADPH dehydrogenase quinone 1''' (NQO1) reduces quinones to hydroquinones. | ||
| + | *'''NADPH dehydrogenase quinone 2''' (NQO2) catayzes electron transfer from NADH to ubiquinone in the mitochondrial respiratory chain<ref>PMID:23086143</ref>. | ||
== Structural highlights == | == Structural highlights == | ||
| - | <scene name='59/595221/Cv/ | + | <scene name='59/595221/Cv/5'>OYE cofactor FMN interacts with the ligand in active site</scene><ref>PMID:11668181</ref>. Water molecules are shown as red spheres. |
</StructureSection> | </StructureSection> | ||
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*NADPH dehydrogenase | *NADPH dehydrogenase | ||
| + | **[[7blf]] – OYE + FMN - fungus<br /> | ||
**[[1oyc]], [[1oya]] – yOYE + FMN - yeast<br /> | **[[1oyc]], [[1oya]] – yOYE + FMN - yeast<br /> | ||
**[[1oyb]] – yOYE + FMN + p-hydroxybenzaldehyde <br /> | **[[1oyb]] – yOYE + FMN + p-hydroxybenzaldehyde <br /> | ||
**[[3tjl]] – SsOYE + FMN + malonate - ''Scheffersomyces stipitis'' <br /> | **[[3tjl]] – SsOYE + FMN + malonate - ''Scheffersomyces stipitis'' <br /> | ||
| + | **[[6s32]] – OYE + FMN + benzamidine – ''Chroococcidiopsis thermalis''<br /> | ||
| + | **[[6s31]] – GsOYE + FMN + benzaldehyde – ''Galdieria sulphuraria''<br /> | ||
| + | **[[6s0g]], [[6s23]] – GsOYE + FMN <br /> | ||
| + | **[[6agz]] – OYE + FMN - ''Pichia''<br /> | ||
| + | **[[3kru]], [[3krz]] – OYE + FMN – ''Thermoanaerobacter pseudethanolicus''<br /> | ||
| + | **[[3atz]] – TcOYE + FMN + benzaldehyde – ''Trypanosoma cruzi''<br /> | ||
| + | **[[3aty]] – TcOYE + FMN <br /> | ||
| + | **[[2gou]], [[2gqa]] – SoOYE + FMN – ''Shewanella oneidensis''<br /> | ||
| + | **[[2gq9]] – SoOYE + FMN + benzaldehyde <br /> | ||
| + | **[[7o0t]] – OYE + FMN – ''Chloroflexus aggregans''<br /> | ||
| + | **[[3hgj]] – TsOYE + FMN + benzaldehyde – ''Thermus scotoductus''<br /> | ||
| + | **[[3hf3]] – TsOYE + FMN <br /> | ||
*NADPH dehydrogenase 1 | *NADPH dehydrogenase 1 | ||
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**[[5v4p]] – yOYE 3 + FMN + p-hydroxybenzaldehyde <br /> | **[[5v4p]] – yOYE 3 + FMN + p-hydroxybenzaldehyde <br /> | ||
**[[5v4v]] – yOYE 3 + FMN + nicotinamide <br /> | **[[5v4v]] – yOYE 3 + FMN + nicotinamide <br /> | ||
| + | |||
| + | *NADPH dehydrogenase 4 | ||
| + | |||
| + | **[[4b5n]] – SoOYE 4 + FMN <br /> | ||
| + | |||
| + | *NADPH dehydrogenase quinone 1 | ||
| + | |||
| + | **[[5a4k]] – hNQO1 (mutant) + FAD - human <br /> | ||
| + | **[[5fuq]], [[4cet]] – hNQO1 (mutant) + FAD + dicoumarol <br /> | ||
| + | **[[4cf6]] – hNQO1 (mutant) + FAD + cibacron blue <br /> | ||
}} | }} | ||
Current revision
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3D Structures of NADPH dehydrogenase
Updated on 15-July-2024
References
- ↑ Ryu JY, Suh KH, Chung YH, Park YM, Chow WS, Park YI. NADPH dehydrogenase-mediated respiratory electron transport in thylakoid membranes of the cyanobacterium Synechocystis sp. PCC 6803 is inactive in the light. Mol Cells. 2003 Apr 30;15(2):240-4. PMID:12803488
- ↑ Feng Y, Li W, Li J, Wang J, Ge J, Xu D, Liu Y, Wu K, Zeng Q, Wu JW, Tian C, Zhou B, Yang M. Structural insight into the type-II mitochondrial NADH dehydrogenases. Nature. 2012 Nov 15;491(7424):478-82. doi: 10.1038/nature11541. Epub 2012 Oct 21. PMID:23086143 doi:http://dx.doi.org/10.1038/nature11541
- ↑ Brown BJ, Hyun JW, Duvvuri S, Karplus PA, Massey V. The role of glutamine 114 in old yellow enzyme. J Biol Chem. 2002 Jan 18;277(3):2138-45. Epub 2001 Oct 19. PMID:11668181 doi:10.1074/jbc.M108453200
