Neuroligin

From Proteopedia

(Difference between revisions)
Jump to: navigation, search
Current revision (08:48, 13 July 2023) (edit) (undo)
 
(2 intermediate revisions not shown.)
Line 11: Line 11:
*'''NLGN-1''' regulates spines and synaptic plasticity<ref>PMID:26880202</ref>. <br />
*'''NLGN-1''' regulates spines and synaptic plasticity<ref>PMID:26880202</ref>. <br />
*'''NLGN-2''' is localized to inhibitory synapses<ref>PMID:15540461</ref>. <br />
*'''NLGN-2''' is localized to inhibitory synapses<ref>PMID:15540461</ref>. <br />
 +
*'''NLGN-3''' is a synapse organizer which shapes normal function and autism disorder<ref>PMID:17897391</ref>. <br />
*'''NLGN-4''' is localized to glyceric post-synapses and regulates retina inhibition<ref>PMID:21282647</ref>. <br />
*'''NLGN-4''' is localized to glyceric post-synapses and regulates retina inhibition<ref>PMID:21282647</ref>. <br />
Line 17: Line 18:
== Structural insights ==
== Structural insights ==
-
The <scene name='42/422448/Cv/4'>NLGN-NRXN complex involves the octahedrally coordinated Ca+2 ion</scene><ref>PMID:18084303</ref>. Water molecules shown as red spheres.
+
The <scene name='42/422448/Cv/5'>NLGN-NRXN complex involves the octahedrally coordinated Ca+2 ion</scene><ref>PMID:18084303</ref>. Water molecules are shown as red spheres.
</StructureSection>
</StructureSection>
== 3D Structures of Neuroligin ==
== 3D Structures of Neuroligin ==
Line 28: Line 29:
**[[5ojk]] - hNLGN-1 cholinesterase domain - human<br />
**[[5ojk]] - hNLGN-1 cholinesterase domain - human<br />
**[[3bix]] - rNLGN-1 cholinesterase domain - rat<br />
**[[3bix]] - rNLGN-1 cholinesterase domain - rat<br />
 +
**[[8gs4]] - hNLGN-2 – Cryo EM<br />
**[[3bl8]] - mNLGN-2 cholinesterase domain – mouse<br />
**[[3bl8]] - mNLGN-2 cholinesterase domain – mouse<br />
 +
**[[7cee]] - mNLGN-3 cholinesterase domain<br />
**[[3be8]] - hNLGN-4 cholinesterase domain – human<br />
**[[3be8]] - hNLGN-4 cholinesterase domain – human<br />
Line 43: Line 46:
**[[5v5v]] - rNLGN-2 cholinesterase domain + MDGA1<br />
**[[5v5v]] - rNLGN-2 cholinesterase domain + MDGA1<br />
**[[5xeq]] - rNLGN-2 cholinesterase domain (mutant) + MDGA1<br />
**[[5xeq]] - rNLGN-2 cholinesterase domain (mutant) + MDGA1<br />
 +
**[[7ceg]] - mNLGN-3 cholinesterase domain + PTP d<br />
}}
}}

Current revision

Dimer of two mouse neuroligin-1 cholinesterase-like domains (magenta and cyan) in complex with two neurexin-beta1 LNS6 domains (salmon and yellow) and Ca+2 ions (green) 3b3q

Drag the structure with the mouse to rotate

3D Structures of Neuroligin

13-July-2023

References

  1. ↑ Fabrichny IP, Leone P, Sulzenbacher G, Comoletti D, Miller MT, Taylor P, Bourne Y, Marchot P. Structural analysis of the synaptic protein neuroligin and its beta-neurexin complex: determinants for folding and cell adhesion. Neuron. 2007 Dec 20;56(6):979-91. PMID:18093521 doi:10.1016/j.neuron.2007.11.013
  2. ↑ Liu A, Zhou Z, Dang R, Zhu Y, Qi J, He G, Leung C, Pak D, Jia Z, Xie W. Neuroligin 1 regulates spines and synaptic plasticity via LIMK1/cofilin-mediated actin reorganization. J Cell Biol. 2016 Feb 15;212(4):449-63. doi: 10.1083/jcb.201509023. PMID:26880202 doi:http://dx.doi.org/10.1083/jcb.201509023
  3. ↑ Varoqueaux F, Jamain S, Brose N. Neuroligin 2 is exclusively localized to inhibitory synapses. Eur J Cell Biol. 2004 Sep;83(9):449-56. PMID:15540461 doi:http://dx.doi.org/10.1078/0171-9335-00410
  4. ↑ Budreck EC, Scheiffele P. Neuroligin-3 is a neuronal adhesion protein at GABAergic and glutamatergic synapses. Eur J Neurosci. 2007 Oct;26(7):1738-48. doi: 10.1111/j.1460-9568.2007.05842.x. PMID:17897391 doi:http://dx.doi.org/10.1111/j.1460-9568.2007.05842.x
  5. ↑ Hoon M, Soykan T, Falkenburger B, Hammer M, Patrizi A, Schmidt KF, Sassoe-Pognetto M, Lowel S, Moser T, Taschenberger H, Brose N, Varoqueaux F. Neuroligin-4 is localized to glycinergic postsynapses and regulates inhibition in the retina. Proc Natl Acad Sci U S A. 2011 Feb 15;108(7):3053-8. doi:, 10.1073/pnas.1006946108. Epub 2011 Jan 31. PMID:21282647 doi:http://dx.doi.org/10.1073/pnas.1006946108
  6. ↑ Zhang C, Milunsky JM, Newton S, Ko J, Zhao G, Maher TA, Tager-Flusberg H, Bolliger MF, Carter AS, Boucard AA, Powell CM, Sudhof TC. A neuroligin-4 missense mutation associated with autism impairs neuroligin-4 folding and endoplasmic reticulum export. J Neurosci. 2009 Sep 2;29(35):10843-54. doi: 10.1523/JNEUROSCI.1248-09.2009. PMID:19726642 doi:http://dx.doi.org/10.1523/JNEUROSCI.1248-09.2009
  7. ↑ Chen X, Liu H, Shim AH, Focia PJ, He X. Structural basis for synaptic adhesion mediated by neuroligin-neurexin interactions. Nat Struct Mol Biol. 2008 Jan;15(1):50-6. Epub 2007 Dec 16. PMID:18084303 doi:10.1038/nsmb1350
Retrieved from "http://52.214.119.220/wiki/index.php/Neuroligin"
Personal tools